Abbott Laboratories Corporation

Other

Lisa M Monteggia

Murali Gopalakrishnan

James P Sullivan

Clark A Briggs

Jean-Marc Roch

Edward B Touma

David G Mc Kenna

David G McKenna

A variant human &#x3b1;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &#x3b1;7 nAChR. Nucleic acid molecules encoding the variant human &#x3b1;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.

Variant human &#x3b1;7 acetylcholine receptor subunit, and methods of production and use thereof

A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.

Variant human &agr;7 acetylcholine receptor subunit, and methods of production and use thereof

A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, receptors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.

Variant human &agr;7 acetylcholine receptor subunit, and methods of production and uses thereof

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Lindenhurst, IL, United States of America

Lisa M Monteggia