University of California

Buck Institute for Research on Aging

Centre National De La Recherche Scientifique

Assistance Publique-hopitaux De Paris

Sorbonne Université

Lisa M Ellerby

Jonathan A Ellman

Melissa J Leyva

Bruce S Dunn

Jeffrey I Zink

Stacey A Yamanaka

Joan S Valentine

Barbara J Bailus

Fumito Nishida

Clinton Nishida

Francesca Farina

Jessica Voisin

Julia Dancourt

In various embodiments constructs are provided for the delivery of an effector molecule into a cell. In certain embodiments the construct comprises a cell penetrating peptide (CPP) attached to an effector that is to be delivered into a cell, where the cell penetrating peptide comprises a Zika cell penetrating peptide (Zika CPP), and the effector is selected from the group consisting of a protein, a nucleic acid, an organic compound, a nanoparticle, a viral particle, and the like.

Zika as a cell penetrating peptide for delivery to the brain

This invention provides novel caspase inhibitors useful for prophylaxis or treatment of a number of pathologies, including, for example, Huntington's disease. In certain embodiments the inhibitors include inhibitors of casepase-3 and/or casepase-6.

Caspase inhibitors and uses thereof

An active biological material encapsulated in a glass is formed using a sol-gel process. A metal alkoxide is mixed with water and exposed to ultrasonic energy at a pH.ltoreq.2 to form a single phase solution which is then buffered to a pH between about 5 and 7. The buffered solution is then mixed with the active biological material and the resultant gel is aged and dried. The dried product is a transparent porous glass with substantially all of the added active biological material encapsulated therein, the biological material retaining a high level of activity.

Sol-gel encapsulated enzyme

Growing community of inventors

Novato, CA, United States of America

Lisa M Ellerby