Dnae Group Holdings Limited

Dna Electronics Limited

Nanomr, Inc.

Lisa-Jo Ann Clarizia

Sergey A Dryga

Eddie W Adams

Victor C Esch

Ravil A Sitdikov

Thearith H Ung

Colin W Dykes

Meghan E Norvell

James H Macemon

Magdalena A Torrance

David K Aley

Erik J Smith

Alexandra Barr

Jaclyn Vandervest

The present invention generally relates to methods of generating antibodies against a species of pathogen that involve identifying the pathogen that is most genetically representative of member of pathogen species and using the identified pathogen to generate an antibody.

Methods for raising antibodies

The invention generally relates to using magnetic particles and magnets to isolate a target analyte from a body fluid sample. In certain embodiments, methods of the invention involve introducing magnetic particles including a target-specific binding moiety to a body fluid sample in order to create a mixture, incubating the mixture to allow the particles to bind to a target, applying a magnetic field to capture target/magnetic particle complexes on a surface, and washing with a wash solution that reduces particle aggregation, thereby isolating target/magnetic particle complexes.

Isolating a target analyte from a body fluid

The invention generally relates to conducting an assay on a sample that isolates a pathogen from the sample and allows for analysis of the pathogen with minimal (i.e., at most 24 hrs of culturing) or no culturing of the pathogen. In certain embodiments, the invention provides methods for identifying a pathogen from a sample that involve obtaining a sample including a pathogen, conducting an assay that isolates the pathogen from the sample, culturing the isolated pathogen for at most about 24 hrs, and analyzing the pathogen.

Analyzing bacteria without culturing

The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.

Methods for isolating a target analyte from a heterogenous sample

Methods for isolating a target analyte from a heterogeneous sample

The invention generally relates to conducting an assay on a sample that isolates a bacterium from the sample, in which the assay isolates as low as about 1 CFU/ml of bacteria in the sample.

Extracting low concentrations of bacteria from a sample

The invention generally relates to compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen.

Compositions for isolating a target analyte from a heterogeneous sample

Growing community of inventors

Albuquerque, NM, United States of America

Lisa-Jo Ann Clarizia