3m Innovative Properties Company

Radius Health, Inc.

Kindeva Drug Delivery, L.p.

Lisa Dick

Ying Di Zhang

Haiyan Zhang

John C Hulteen

Joan T Moseman

Gary Hattersley

Kenneth Brown

Daniel Dohmeier

Alan Harris

William L Stebbings

Jamal Saeh

Ehab Hamed

Terry Lee Smith

Jun-Ying Zhang

Ding Wang

Jerome C Porque

Ying Zhang

Joan Moseman

Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.

Formulations of abaloparatide, transdermal patches thereof, and uses thereof

A medical device comprising a composition comprising a therapeutically active amount of active agent, a zinc compound, and an array of microneedles. The zinc compound may be selected from the group consisting of zinc, pharmaceutically acceptable salts of zinc, and mixtures thereof. At least a portion of the composition is present as a coating on at least a portion of the microneedles. Methods of delivering a therapeutically active agent to a mammal using compositions of the disclosure are also included.

Zinc compositions for coated microneedle arrays

Provided is a method of making microarrays that includes providing a substrate with discrete first microfeatures that have a first profile, and depositing vapor-coated materials onto the first microfeatures to form second microfeatures having a second profile that is substantially different from the first profile. Also provided is a method of adding a replication material to the vapor-coated microfeatures to form a mold. Microarrays made by this method can be used as substrates for surface-enhanced Raman spectroscopy (SERS).

Method of making microarrays

A method of obtaining a surface-enhanced optical property of an analyte using a flexible structured substrate having a metal layer conformably disposed on nanostructure, a flexible structured substrate, and a method of making the same.

Surface-enhanced spectroscopic method, flexible structured substrate, and method of making the same

Growing community of inventors

Afton, MN, United States of America

Lisa Dick