University of Pittsburgh

National Institutes of Health, a Component of the US Dept. of Health & Human Services

University of Louisville Research Foundation, Inc.

Other

Lisa C Rohan

Barry R O'Keefe

Tinoush Moulaei

Joshua L Fuqua

Lindsay F Kramzer

Kenneth E Palmer

Galit Regev

Provided herein are stable, dissolvable films containing active ingredients, such as antimicrobial composition, antiviral compositions, or anti-retroviral compositions for intravaginal or intrarectal placement to provide prophylaxis against viral infections.

Vaginal films

The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.

Griffithsin mutants

Hot melt extrusion is disclosed as a process for forming vaginal drug delivery films. The methods involve extruding a composition comprising one or more active pharmaceutical ingredients and one or more polymer carriers at an elevated temperature through a die to thereby provide the film. Films prepared by hot melt extrusion are also described.

Hot melt extrusion for pharmaceutical vaginal film products

Growing community of inventors

Pittsburgh, PA, United States of America

Lisa C Rohan