US Government as Represented by the Secretary of the Army

Lisa A Ware

Sheetij Dutta

David E Lanar

Lalitha P V Nair

In this application is the expression and purification of a recombinant(SalI) PvMSP-1 p42. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant PvMSP-1 p42 is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.

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In this application is described the expression and purification of a recombinant(3D7) AMA-1 ectodomain. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant AMA-1 is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.

In this application is described the expression and purification of a recombinant(3D7) AMA-1 ectodomain. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant AMA-1 is useful as a diagnostic reagent, for use in antibody production, and as a protein for use alone, or as part of, a vaccine to prevent malaria.

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Silver Spring, MD, United States of America

Lisa A Ware