Endologix, Inc.

Radiance Medical Systems, Inc.

Stat-chem Inc.

Endology, Inc.

Lisa A Tam

Brett A Trauthen

James Huntington Dabney

Michael D Crocker

Michael H Burnam

Martin J Patko

Robert Fazio

Gary Strathern

Edward F Smith

The invention discloses a system, method and medical device for measuring various hemoglobin derivatives, such as oxyhemoglobin, reduced hemoglobin, partial hemoglobin, carboxyhemoglobin, methemoglobin and sulfhemoglobin in whole or in hemolyzed blood. The novel method uses a statistical approach to enable the design of a portable co-oximeter. This portable co-oximeter utilizes compact light sources, such as light emitting diodes or light emitting lasers, to emit light in the visible region. Being portable, the device is a point-of-care device that can be used in emergency situations by paramedics, in the emergency room, and in a physicians office to detect and measure the concentrations and/or percentages of functional and non-functional hemoglobin derivatives in a patient's blood.

Portable co-oximeter

Disclosed is a thin film radiation source, which may be used to deliver a radioactive dose to a site in a body lumen. The source comprises a thin flexible substrate, and a layer of radioisotope attached thereto. The source may further comprise additional layers such as one or more tie layers disposed between the substrate and the radioisotope layer and one or more outer coating layers. In one embodiment, the source is wrapped around an inflatable balloon. Inflation of the balloon at a treatment site positions the source directly adjacent to the vessel wall, and allows irradiation of the site following or simultaneously with a balloon angioplasty, stent implantation, or stent sizing procedure.

Method for delivering radiation to an intraluminal site in the body

Disclosed are sources and methods for delivering a radioactive dose to a site in a body lumen. The sources are preferably mounted on a balloon or other expandable or deployable mechanical structure. The source and methods enable delivery of a clinically significant dose of radiation into a vessel wall in a relatively short time while using a relatively low activity. The sources also enable delivery of a substantially uniform dose into the vessel wall, whether or not such delivery is through the wall of a stent.

Radiation delivery catheters and dosimetry methods

A sealed radiation source, which may be used to deliver a radioactive dose to a site in a body lumen. The source comprises a thin flexible substrate, and a layer of radioisotope attached thereto. The source may further comprise additional layers such as one or more tie layers disposed between the substrate and the radioisotope layer and one or more outer coating layers. In one embodiment, the source is wrapped around an inflatable balloon. Inflation of the balloon at a treatment site positions the source directly adjacent to the vessel wall, and allows irradiation of the site following or simultaneously with a balloon angioplasty, stent implantation, or stent sizing procedure.

Multi layer radiation delivery balloon

Thin film radiation source

Disclosed is a radioactive tubular prosthesis formed by rolling a flexible sheet around a longitudinal axis. Preferably, the prosthesis is self expandable under the radially outwardly directed spring bias of the rolled sheet. At least a portion of the sheet is provided with a coating comprising at least one radioisotope.

Growing community of inventors

Lake Forest, CA, United States of America

Lisa A Tam