Board of Trustees of the University of Arkansas

United States of America, As Represented by the Secretary of Agriculture

Lisa A Newberry

Billy M Hargis

Lisa Bielke

Guillermo Tellez

Ann M Donoghue

Daniel J Donoghue

Gerardo Nava

Stacy E Higgins

John K Skeeles

Disclosed are methods of selecting wide host range bacteriophage capable of growing in a plurality of bacteria including pathogenic and non-pathogenic bacteria and bacteriophage selected by the methods. Also disclosed are methods of treating a subject infected with a pathogenic bacterium using bacteriophage and methods of decontaminating objects using bacteriophage. Also disclosed are methods of producing vaccines. In another aspect, methods of determining bacterial viability and methods of improving the sensitivity of a biosensor using wide host range bacteriophages are disclosed.

Method for bacteriophage delivery and amplification

Infectious bursal disease viruses were isolated from broiler chickens experiencing proventriculitis in, for example, Oklahoma, Texas, West Virginia, and California. Chicken virus isolates Texas RB 3, Texas RB 4, HBS, F57-7, W/L 39, GAR 1, and the like have been isolated. These viruses are some of the major causes of this condition and can be utilized as or in a vaccine to prevent the disease condition. The viruses are a significant finding in the search for a causative agent for proventriculitis in broiler chickens and as such may be utilized in the development of a vaccine or vaccines. The viruses can be attenuated to be used as a modified live vaccine or utilized in an inactivated form in a killed vaccine.

Poultry virus isolates and method

Growing community of inventors

Benton, AR, United States of America

Lisa A Newberry