California Institute of Technology

Washington University

Liren Zhu

Lihong V Wang

Jinyang Liang

Cheng Ma

Taewoo Kim

Lei Li

Peng Wang

Compressed ultrafast photography (CUP) techniques that produce spatially encoded images from a first series of images where each spatially encoded image has first and second views of an image of the first series of images superimposed with a pseudo-random binary spatial pattern, that transform the first view and/or the second view such that the first view is rotated 180° relative to second view, that deflect each spatially encoded image by a temporal deflection distance that varies as a function of time-of-arrival, and that integrate the spatially encoded images into a CUP image.

Phase-sensitive compressed ultrafast photography systems and methods

Disclosed herein are systems and methods of phase-sensitive compressed ultrafast photography (pCUP). In some embodiments, a pCUP system comprises: a dark-field imaging system, and a compressed ultrafast photography (CUP system). The dark-field imaging system may comprise a laser source configured to illuminate the subject with a laser pulse; and a beam block configured to pass laser light scattered by the subject as a first series of phase images and block laser light not scattered by the subject. The CUP system may comprise: a spatial encoding module configured to receive the first series of phase images and to produce a second series of spatially encoded phase images; and a streak camera configured to receive the second series of spatially encoded phase images, to deflect each spatially encoded phase image by a temporal deflection distance, and to integrate the deflected phase images into a single raw CUP image.

A single-impulse panoramic photoacoustic computed tomography (SIP-PACT) system for small-animal whole-body imaging is disclosed. In addition, a dual-speed of sound image universal back-projection reconstruction method is disclosed. Further, a PACT system for imaging a breast of a subject is disclosed.

Single-impulse panoramic photoacoustic computed tomography (SIP-PACT)

Systems and methods for stereo-polarimetric compressed-sensing ultrafast imaging.

Stereo-polarimetric compressed ultrafast photography (SP-CUP) systems and methods

A system and method for compressed-sensing ultrafast photography for two-dimensional dynamic imaging is disclosed. The system and method may capture non-repetitive time-evolving events at up to about 100 billion frames per second. In an aspect, a digital micromirror device (DMD) may be added as the spatial encoding module. By using the DMD and applying the CUP reconstruction algorithm, a conventional 1D streak camera may be transformed to a 2D ultrafast imaging device. The resultant system may capture a single, non-repetitive event at up to 100 billion frames per second with appreciable sequence depths (up to about 350 frames per acquisition). In another aspect, a dichroic mirror may be used to separate signals into two color channels, and may further expand CUP's functionality into the realm of four-dimensional x, y, &#x3bb;, t ultrafast imaging, maximizing the information content that may be simultaneously acquired from a single instrument. On the basis of compressed sensing (CS), CUP may encode the spatial domain with a pseudo-random binary pattern, followed by a shearing operation in the temporal domain, performed using a streak camera with a fully opened entrance slit. This encoded, sheared three-dimensional (3D) x, y, t scene may then be measured by a 2D detector array, such as a CCD, within a single snapshot. The image reconstruction process follows a strategy similar to CS-based image restoration&#x2014;iteratively estimating a solution that minimizes an objective function. However, unlike CS-based image restoration algorithms, which target the reconstruction of a 2D x, y image, CUP reconstruction recovers a 3D x, y, t movie by applying regularization over both the spatial domain and the temporal domain.

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St. Louis, MO, United States of America

Liren Zhu