Nitto-denko Corporation

Liping Wang

Wenbin Ying

Haiqing Yin

Yuwei Wang

Dong Liu

Roger C Adami

Scott D Edmondson

Gregori J Morriello

Ihor E Kopka

Stephen D Goble

Lehua Chang

Nam Fung Kar

Roger Adami

Sookhee Nicole Ha

Dong-Ming Shen

Richard Berger

Bing Li

Chris R Moyes

Cheng Zhu

Compositions for making a solid lyophile of one or more nucleic acid active agents, which can be reconstituted as a drug product. The composition can include an aqueous suspension of lipid nanoparticles in a pharmaceutically acceptable solution, wherein the lipid nanoparticles encapsulate one or more nucleic acid active agents, a dextrin compound, and a saccharide compound. The nucleic acid active agents can be RNAi molecules capable of mediating RNA interference, as well as other RNAs and oligonucleotides.

Compositions and methods for nanoparticle lyophile forms

This invention provides compositions for making a solid lyophile of one or more nucleic acid active agents, which can be reconstituted as a drug product. The composition can include an aqueous suspension of lipid nanoparticles in a pharmaceutically acceptable solution, wherein the lipid nanoparticles encapsulate one or more nucleic acid active agents, a dextrin compound, and a saccharide compound. The nucleic acid active agents can be RNAi molecules capable of mediating RNA interference, as well as other RNAs and oligonucleotides.

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Carlsbad, CA, United States of America

Liping Wang