Chinese Academy of Sciences

Dalian University of Technology

East China University of Science and Technology

Liping Lin

Jian Ding

Wei Lu

Yi Chen

Hong Iris Zhu

Zehong Miao

Yufang Xu

Xuhong Qian

Baoyuan Qu

Heyong Gao

Yonggang Li

New camptothecin derivatives with the following structure of the formula (I), their use and the pharmaceutical compositions containing the same. The compounds of the present invention have good anti-tumor activities and good solubility in water, and can be used in development of medicines. 

Camptothecin derivatives and their use

The invention discloses novel sulfur-containing naphthalimide derivatives, and the preparation and uses thereof. The conjugated plane of naphthalimide derivatives of the invention is enlarged by incorporating 5-or 6-membered heteroaromatic ring and/or introducing S heteroatom, thus increasing the anti-tumor activity of naphthalimide. The compounds of the invention displays significant inhibiting activities to the proliferation of various tumor cells such as human lung cancer, gastric cancer, liver cancer, leucocythemia and the like. The inhibition of cell proliferation is dose-dependent.

Sulfur-containing naphthalimide derivatives

Growing community of inventors

Shanghai, China

Liping Lin