Bionomics Inc.

Lioudmila A Campbell

Christopher L Reyes

Peter Chu

Kristen Michelle Smith

John Thomas Norton

Farbod Shojaei

Eric Ailor

Christopher Reyes

Disclosed herein are humanized anti-LGR5 antibodies for the treatment of cancer. Antibodies disclosed herein may bind LGR5 without disrupting LGR5-RSPO1 binding or signaling, and may disrupt LGR5 signaling through Wnt that is independent of RSPO1. Also disclosed are heavy and light chain polypeptide sequences for the biding of LGR5, for example without disrupting LGR5-RSPO binding or signaling.

Humanized antibodies that bind LGR5

Disclosed herein are anti-LGR4 antibodies for the treatment of cancer. Antibodies disclosed herein may bind LGR4 without disrupting LGR4-RSPO1 binding or signaling, and may disrupt LGR4 signaling through Wnt that is independent of RSPO1. Also disclosed are heavy and light chain polypeptide sequences for antibodies that bind LGR4, for example without disrupting LGR4-RSPO binding or signaling.

Antibodies that bind LGR4, their use in inhibiting neoplastic cells and in treating tumors

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Del Mar, CA, United States of America

Lioudmila A Campbell