Chemagis Ltd.

Lior Zelikovitch

Joseph Kaspi

Oded Arad

Moshe Bentolila

Vladimir Naddaka

Shady Saeed

Michael Brand

Mohammed Alnabari

Oded Friedman

Moty Shookrun

Dionne Montviliski

Liu Xing

Ada Salman

Michal Hasson

Hila Isenberg

Meital Shiffer

Efrat Manoff

Orna Kurlat

Irina Gribun

Huang Anli

The present invention provides a crystalline donepezil maleate, which is used as an intermediate in the preparation of donepezil hydrochloride. Also provided are novel processes for producing same in substantially pure form and a process for producing pharmaceutically pure amorphous donepezil hydrochloride therefrom.

Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride

A novel process is disclosed for producing Imatinib, using the precursor 2-chloro-4-(3-pyridyl)-pyrimidine, thus improving Imatinib preparation via an alternative synthetic route, avoiding the use of the toxic reagent cyanamide.

Process for preparing Imatinib

Provided is a process for purifying a letrozole product that contains an isoletrozole impurity, which process preferably includes converting at least a portion of the isoletrozole impurity into 4,4'-dicyanobenzophenone and removing 4,4&#x2032;-dicyanobenzophenone, to produce a purified letrozole product.

Letrozole purification process

The present invention provides a process for preparing 4-amino-1-isobutyl-1H-imidazo[4,5-c]quinoline (Imiquimod) of formula (I). The process comprises heating 4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline of formula (II) with formamide, and optionally with bubbling of gaseous ammonia to afford Imiquimod of formula (I). According to the present invention, by using this process and novel purification methods, essentially as described herein, highly pure Imiquimod is obtained.

Process for preparing Imiquimod

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Mazkeret Batia, Israel

Lior Zelikovitch