Omrix Biopharmaceuticals Inc.

Ethicon, Gmbh

Guangzhou Bioseal Biotech Co. Ltd

Guangzhou Science Co., Inc.

Lior Weissman

Israel Nur

Tamara Byk-Tennenbaum

Erez Ilan

Sivan Doron

Eve Montia

Oleg Belyaev

James Galloway

Nina Raver-Shapira

Itai Podoler

Liliana Bar

Eyal Sheetrit

Dana Sella

Caixia Jiang

Baochang An

The invention relates to a viral inactivated biological liquid or dry mixture and to its preparation. Principally, the invention relates, but is not limited, to a mixture derived from a platelet source.

Viral inactivated biological mixture

The present invention is directed to methods of enhancing toxicity of a glycolytic dependent compound towards a cancerous tissue and/or organ in a subject, the method being comprised of targeting the glycolytic dependent compound to the cancerous tissue and/or organ by placing oxidized regenerated cellulose (ORC) and/or oxidized cellulose (OC) in direct connection with the cancerous tissue and/or organ, and administering the glycolytic dependent compound to the subject by a systemic route.

Method of treating a disease using a glycolytic dependent compound

Provided is a method of enhancing toxicity of a glycolytic dependent compound towards a cell, tissue and/or organ e.g. a diseased cell, tissue and/or organ, the method comprises contacting Oxidized Regenerated Cellulose (ORC) and/or Oxidized Cellulose (OC); and a glycolytic dependent compound with the cell, tissue and/or organ. The ORC and/or OC; and the glycolytic dependent compound are contacted with the cell, tissue and/or organ in a non-blended form.

The present invention is directed to methods for the production of thrombin from a source of prothrombin using a given BaSOreagent as an adsorbent of prothrombin as well as methods for evaluating the suitability of a given BaSOreagent for use in preparation of thrombin. In at least one embodiment, the method includes contacting a sample of the given BaSOreagent with a source of prothrombin to obtain BaSO-adsorbed prothrombin, and subsequently evaluating the pro-coagulant activity of the BaSO-adsorbed prothrombin. In another embodiment, the method includes the step of evaluating relative to the pro-coagulant activity of normal mammalian plasma.

Method for preparation of thrombin

The invention relates to a prosthetic for repairing an opening or a defect in a soft tissue, to its preparation and use. The prosthetic of the invention comprises a substrate viscerally-coated with stabilized and non-completely dry fibrin. The prosthetic displays reduced postoperative complications following its implantation.

Implantable device comprising a substrate pre-coated with stabilized fibrin

The invention relates to a viral-safe platelet extract, to its preparation and use. The extract comprises a mixture of biologically active platelet derived factors. Advantageously, the extract comprises a balanced proportion of the factors and is non-clottable.

Viral inactivated platelet extract, use and preparation thereof

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Nes-Ziona, Israel

Lior Weissman