Genegrafts Ltd.

Rappaport Family Institute for Research in the Medical Sciences

Lior Gepstein

Yair Feld

Shimon Marom

Tal Bresler

Meira Frank

Reem Miari

Udi Nussinovitch

An isolated polypeptide comprising, contiguously, a first amino acid sequence being at least 90% homologous to amino acid coordinates 1-398 of SEQ ID NO: 2, a tryptophan residue and a second amino acid sequence being at least 90% homologous to amino acid coordinates 400-523 of SEQ ID NO:2. Also provided are polynucleotide sequences encoding this polypeptide and uses of same in the treatment of medical conditions associated with ion channel insufficiency.

Polynucleotides and polypeptide of human KV1.3, compositions comprising same and methods of using same

Polynucleotide expression constructs, populations of cells and methods of treating diseases caused by dysfunction in, or damage to, excitable tissues are provided.

Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues

A method of modifying the electrophysiological function of an excitable tissue region of an individual is provided. The method includes the step of implanting cells into the excitable tissue region. Each implanted cell is (a) capable of forming gap junctions with at least one cell of the excitable tissue region; and (b) capable of forming a functional ion channel or transporter, wherein the functional ion channel or transporter is capable of modifying the electrophysiological function of the excitable tissue region.

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Haifa, Israel

Lior Gepstein