Becton Dickinson and Company Limited

Genentech, Inc.

Becton Dickinson France S.a.s.

Forsight Vision4, Inc.

Hoffmann-La Roche Inc.

Sanofi

Becton Dickinson France

F. Hoffmann-La Roche Ag

Lionel Vedrine

Richard A Cronenberg

Ralph Lee Sonderegger

Paul G Alchas

Hubert Jansen

Atul Patel

Laurent Barrelle

Curt G Bingham

Weston F Harding

Glade Harold Howell

Chris N Cindrich

Asif Fayyaz

Ruane S Jeter

Matthew Dylan Sweeney

Alex Lastovich

Bart David Peterson

Frederic Perot

Mukund R Patel

Roger Groskopf

Scott M Nunn

Dnyanesh A Talpade

Mark Sponsel

Steven Nelson Roe

Gary M Searle

Peter Skutnik

Jean Pierre Grimard

Keith N Knapp

Roman Tunkel

Christopher N Cindrich

Robert Banik

Joshua D Horvath

Pradeep K Dhal

Min Wei

Alexander George Lastovich

Mark Robson Humphries

Corey Christensen

Peter W Heyman

Marina S Korisch

Dnyanesh Talpade

Eric Denis

Samuel Bernier

Emmanuel Delarue

Keith Bianchi

Pierre Goldbach

Craig Harvey Nelson

Bill Hartsig

Mukund Patel

Ariel Waitz

Michel Guillory

Patrick Begley

Michael C Ratigan

Paul Alchas

Mayumi Naito Bowen

Judith L Doyle

Steven L Koziol

Heather L Flores

Ajay Deshmukh

A Wesley Prais

Kewei Yang

Geoffrey Colin Wise

Bruno Cocheteux

Ying Xu

Nathan A Goltz

Florian Wildenhahn

Ivy Lin

Mathieu Rigollet

Robert Müller

Elisabeth Schaible

Edward Schwarb

Frank Bamberg

Aaron D Chesterman

Eric Borin

Carys Eleri Lee

Baboo Dushyantsingh Goordyal

Gary Searle

Scott Nunn

Geoffrey Wise

Steven N Roe

Nicholas Oliver Harding

Christina Laskar

Roger W Groskopf

An ocular implant system including an ocular implant sized and shaped to be inserted at least partially into an eye; a carrier member with a shell having a central channel extending at least partially through the shell from a proximal end towards a distal end of the shell. A guide sleeve removably attached within at least a first region of the central channel of the shell and defining a proximal port into the central channel that is accessible from the proximal end of the shell. An implant holder removably attached within at least a second region of the central channel of the shell adjacent to a distal end of the guide sleeve and having a pair of graspers adapted to releasably secure the implant at a distal end of the implant holder. Related devices, systems, and/or methods are described.

Ocular implant delivery device and method

The needless vial assemblies described herein allow for the access to the contents of a vial, such as a medication, using a syringe without a needle. In some designs, the vial includes a vial neck, which is itself a syringe interface. The vial assemblies also include a cap with a plug, which can be used to seal the vial assembly. The present disclosure further provides methods of filling a vial assembly and methods of filling a syringe using the vial assemblies described herein.

Vial assembly with luer fitting

The subject invention provides a drug delivery device for injecting medicament which includes a tubular reservoir; a stopper slidably disposed in the reservoir; a spring for moving the stopper in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle; and an actuator. Activation of the actuator causes the spring to move the stopper and the needle driver to displace the needle. The needle moves relative to, and separately from, the reservoir with the needle being displaced. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.

Drug delivery device

Apparatus and methods for delivering medicament. The apparatus may include a fitting for a fluid dispenser. The fitting may include a detent that is configured to limit insertion of the dispenser into the fitting by contacting a terminal surface of the dispenser; and a seal for sealing against the surface. The apparatus may include an insert for the fitting. The insert may include a gasket to seal against the terminal surface of the dispenser; a proximal rim to engage a lateral wall of the dispenser; and a connector fixed to the gasket and the rim. The apparatus may include a coupler to engage a pre-filled dispenser; and a body defining a passageway that is configured to be placed in fluid communication with the dispenser. The apparatus may include a dispenser that includes a detent and a seal. The detent may limit insertion of the dispenser into a fitting.

Apparatus and methods for low-volume medicament delivery

A syringe () has a longitudinal body () with an interior () in which a pharmaceutical substance is arranged, a needle connected to one longitudinal end of the body () and a rigid needle shield () encasing the needle. The rigid needle shield () is essentially water vapour tight. The syringe () according to the invention allows for preventing needle clogging and, thus, proper provision of pharmaceuticals, particularly by subcutaneous, intramuscular or ocular injection.

Syringe and method of preparing syringe

Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.

Versatile syringe platform

Apparatus and methods for delivering medicament to a patient. The apparatus may include elements with different capacities to attenuate or absorb sterilizing radiation. The apparatus may include a medicament delivery assembly with interactive elements for dose-setting, priming and medicament ejection. The assembly may include a chamber housing a radiation-sensitive medicament present in the apparatus during sterilization by electron beam. The assembly may include an actuator chassis, a drive mechanism, a needle-priming mechanism and a fluid-displacement mechanism including a fluid-displacement member. The chassis may be fixed, relative to an outlet, to the chamber. The member may be slidingly and/or threadingly engaged with the chassis, and may be configured to move relative to the outlet to deliver the medicament through the outlet. Assembly elements may be nested coaxially and/or stacked axially. The assembly may include at least one hollow region. The hollow region may reduce beam attenuation or reduce radiation absorption.

Sterile sealed heterogeneous medicament delivery device

Apparatus and methods for lyophilizing and sealing a medicament within a medical delivery device having an opening. The apparatus may include a stopper for sealing the opening. The stopper may have one or more elongated members extending from a base, in a direction that is parallel to a central axis of the base. One or more of the members may be set radially away from the axis and define a coaxial central well. The member or members may define a void. The elongated member or members may engage a device inner wall and support the base away from the opening. The void may provide gas exchange between a device interior and a device exterior. The gas may be a lyophilization byproduct that escapes from the device interior between the inner wall, the base and the member or members. The stopper may be advanced into the device to seal the opening.

Apparatus and methods for sealing a medicament within a medical delivery device

Provided is an extended use self-contained, wearable medical device. The device is preferably configured with an infusion deployment mechanism for variably inserting and retracting an infusion needle to different depths, or completely retracting the infusion needle from the infusion site and then re-inserting the infusion needle after a predetermined period of time, throughout an infusion cycle for extending the viability of the infusion site. Another embodiment comprises dual needle deployment mechanisms which may also variably insert and retract the infusion needles. A flow sensor is preferably provided for detecting the stoppage of flow through the infusion cannula and signaling the needle deployment mechanism to attempt infusion at a different depth or to deploy a second infusion needle. A re-fillable reservoir assembly is preferably provided for supplying a drug over the extended use of the device. Another embodiment comprises a partially reusable and partially disposable medical device implementing the above features.

Extended use medical device

In one aspect of the subject invention, a drug delivery device is provided which includes a reservoir for containing a medicament and has a proximal end and a distal end, the medicament including a suspension of solids in a liquid carrier. Further, the drug delivery device includes a needle in fluid communication with the reservoir and having a distal end for injection into a patient, and a proximal end in the reservoir. An accumulation surface is defined at least partially about the needle, distally of the proximal end of the needle. The accumulation surface defines a distally-extending indentation which is sized and shaped to collect, during use, solids that come out of suspension. Advantageously, with the subject invention, the accumulation surface allows for solids to accumulate at a location spaced from the proximal end of the needle, thereby minimizing the possibility of clogging the needle.

Drug delivery device for drug suspensions

A device () for delivering a medicament into a patient's body by injection into or through the patient's skin, including a main body having a top enclosure () and a bottom enclosure (), a reservoir () disposed within the main body for containing the medicament, and an injection needle () for penetrating the skin of the patient, the needle () having a lumen and selectively communicating with the reservoir (). The device also includes a pressurizing system () for selectively pressurizing the reservoir (). In a pre-activated position, the pressurizing system () contacts and compresses the reservoir () to reduce the initial volume of the reservoir (), thereby allowing for partial filling of the reservoir ().

Self-injection device

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Palo Alto, CA, United States of America

Lionel Vedrine