Biomerieux, Inc.

Centre National De La Recherche Scientifique

Gen-Probe, Inc.

Universite Joseph Fourier Domaine

Université Joseph Fourier

Biomerieux Sa

Lionel Menou

Ali Laayoun

Michael McClellan Becker

Kenneth A Browne

Mitsuharu Kotera

Emmanuelle Trevisiol

Jean Lhomme

Matthew C Friedenberg

Eloy Bernal-Mendez

Eloy Bernal Mendez

Cecile Bourget

Christelle Tora

Aloke R Banerjee

Fred F Hajjar

Aloke Raj Banerjee

Cécile Bourget

The present invention relates to a method for labeling biological molecules of interest contained in a biological sample, consisting in: A method for treating a biological sample is also disclosed. Said invention is preferably used in a manual or automated method for purifying nucleic acids.

Method for labeling or treating a biological sample containing biological molecules of interest, in particular nucleic acids

The present invention relates to a temperature-stable labeling reagent of formula: in which The present invention also describes a method for synthesizing said markers as well as applications for labeling biological molecules, in particular nucleic acids, with a labeling reagent carrying the diazomethyl functional group. The invention finds a preferred application in the field of diagnosis.

Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules

A process of fragmenting and labeling a synthetic or natural nucleic acid, comprising the steps of providing a mixture containing a nucleic acid, a labeling agent containing a detectable label, and at least one multivalent metal cation in a substantially aqueous solution; chemically fragmenting the nucleic acid in the mixture to produce a multiplicity of nucleic acid fragments; and attaching at least one label to at least one of the nucleic acid fragments to produce a detectably labeled nucleic acid fragment.

Process for labeling a nucleic acid

Growing community of inventors

Saint Genis Laval, France

Lionel Menou