Overture Life, Inc.

Lionel Matthys

Pablo Carasa Ruiz

Santiago Munne

Joana Alexandra Sales Fidalgo

Daniel Garcia Alonso

Sara Alvarez Arguelles

Cristina Dosda Munuera

David Cancio Villalonga

José Antonio Horcajadas Almansa

Luis Morgado García

Cristina Dosdá Munuera

Disclosed herein are cryostorage devices, systems, and methods for cryopreservation or vitrification of biological materials, such as oocytes and embryos. These cryostorage devices can include a capillary straw with the dual functionality for loading/unloading a sample. The devices can also include a self-sealing mechanism and an adapter for coupling with pipettes to enable loading of a predetermined volume of sample. The devices can also include a removable cap to protect the capillary during long-term cryostorage. Methods described herein relate to the manual or automated use of such devices.

Cryostorage device

Disclosed herein are microfluidic devices and methods to deliver concentration gradients to biological material such as oocytes and embryos for the purpose of cryopreparation, cryopreservation, or thawing. Cryopreservation methods, such as vitrification, involve the use of cryoprotectants to reduce formation of damaging ice crystals in cells during freezing. Microfluidic devices and methods described herein improve cell viability and efficiency during handling and cryopreservation of biological materials.

Microfluidic devices and methods for delivering solutions to biological material

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Madrid, Spain

Lionel Matthys