Institut Curie

Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Chanel Parfums Beaute

Institute for Cancer Research

Institut De Genetique Et De Biologie Moleculaire Et Cellulaire

Institute for Cancer Research D/b/a the Research Institute of Fox Chase Cancer Center

Institut De Genetique Et De Biologie Moleculaire Et Cellularire

Lionel Larue

Alfonso Bellacosa

Vikram Bhattacharjee

Pietro Mancuso

Rossella Tricarico

Tim Yen

Gaelle Saintigny

Christian Mahe

Florian Rambow

Irwin Davidson

The invention provides compositions, kits, and methods for inducing growth arrest, differentiation, or senescence of cancer cells that express thymine DNA glycosylase, and treating the cancer accordingly. The methods comprise inhibiting expression or biologic activity of thymine DNA glycosylase in cancer cells. Inhibition of thymine DNA glycosylase in cancer cells may induce the cells to revert to a healthy, non-cancerous phenotype and/or may induce the cells to senesce. Cancer cells include melanoma, lung, prostate, pancreatic, ovarian, brain, colon, recto-sigmoid colon, and breast cancer cells.

Inhibition of thymine DNA glycosylase in the treatment of cancer

At least one microRNA selected from among hsa-miR-330, hsa-miR-7 and hsa-miR-137, the mature forms thereof, and the precursors thereof, for depigmenting the skin, and an in vitro method for identifying depigmenting compounds, which includes the steps of: a) placing at least one test compound in contact with a sample of melanocytes; b) measuring the expression or activity of at least one microRNA selected from among miR-330, miR-7 and miR-137, the mature forms thereof, and the precursors thereof, in the melanocytes; c) selecting the compounds for which at least 20% activation of the expression or of the activity of at least one of the microRNAs is measured in the melanocytes treated in a) by an element for comparing with the untreated melanocytes.

Use of microrna molecules to influence skin pigmentation

Growing community of inventors

Paris, France

Lionel Larue