Societe L'oreal Sa

L'oreal

Loreal Sa

Nestec S.a.

Other

Societe Des Produits Nestle S.a.

Lionel Breton

Olivier De Lacharriere

Yann Mahe

Nathalie Pineau

Maria Dalko

Jean-Baptiste Galey

Richard Martin

Audrey Gueniche

Christel Liviero

Florence Girerd

Isabelle Nonotte

Jacques Leclaire

Catherine Cohen

B&eacute;atrice Renault

Olivier De La Charriere

Isabelle Castiel

Jacqueline Dumats

Lucien Paul Aubert

Markus Baur

Isabelle Bureau-Franz

Francois Couzy

Roland Jourdain

Odile Destree

Michela Zuccolo

Oliver De Lacharriere

Raluca Lorant

Pascal Arnaud

Pierre Potier

Bruno Bernard

Annick Mercenier

Francis Pruche

Jalil Benyacoub

Stephanie Blum-Sperisen

Albert Duranton

Pascal Hilaire

Lien Bui-Bertrand

Jean-Francedillaois Nadaud

Chantal Fanchon

Catherine Gerst

Pierre Tachon

Herv&eacute; Pageon

Jean-Fran&ccedil;ois Michelet

Nelly Billoni

Dominique Fagot

Stevens Kastrup Rehen

Mauro Maccarrone

Fran&ccedil;oise Picot

Pierre Desolle

Guénolé Prioult

Emile Benechie

Martine Li

Rodrigo De Vecchi

Marilia Zaluar

Olivier Ballevre

Stéphanie Blum-Sperisen

The present invention relates to the field of stem cell biology, in particular the linage specific differentiation of pluripotent or multipotent stem cells. Specifically described are methods to direct the lineage specific differentiation of hiPSC to sensitive neurons or neuronal fibers innervating the human skin, such as neural crest stem cells (NCPCs) and here called peripheral sensory neurons (PSNs) using novel culture conditions. It is also described a method for screening a biological agent in vitro. The PSNs obtained using the methods of the present invention are further contemplated for various uses including, but limited to, use in in vitro tests or disease modelling, such as drug discovery assays, cell therapy on a higher scale, detecting a range of skin irritants and other compounds of interest, for studying skin aging mechanism, and for producing a dermocosmetic product. Also, it is contemplated the use of ligands in vitro for checking the differentiation and/or activation of the PSN cells, produced by the method of the invention, and the PSN cells, produced by the method of the invention.

Method of human periferic sensory neurons differenciation from human stem cells and uses thereof

Cosmetic use of an effective amount of a lysate of at least one microorganism of the genusspecies and/or one of its fractions in treating and/or preventing dryness and/or associated disorders of a keratinous substance.

Cosmetic use ofspecies lysate for the treatment of dryness

An orally administrable composition for the photoprotection of the skin which comprises the combination of i) at least one probiotic lactic acid bacterium or a culture supernatant thereof, and ii) at least one carotenoid or derivative, included into an orally acceptable carrier.

Orally administrable composition for the photoprotection of the skin

The present invention relates to the topical use ofsubsp.CNCM I-2618, as a pro-pigmenting agent, in particular in the prevention and/or treatment of alterations of skin and/or hair color homogeneity and for creating a uniform complexion.

Use of probiotic micro-organisms as an agent that promotes the synthesis of melanin

Cosmetic use of an effective amount of at least one lysate of at least one microorganism of the genusspecies and/or a fraction thereof, for preventing and/or treating a skin disorder in the case of sensitive skin.

Use of a lysate of bifidobacterium species for treating sensitive skin

Red blotches on the skin such as those associated with environmental stresses, or red blotches associated with a skin disorder, for example those occurring during rosacea, are treated/reduced by administering to individuals afflicted therewith, thus effective amounts of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which includes at least one non-sulfurous mineral and/or thermal water, e.g., an extract derived from the bacterium, in particular the strain ATCC 15551, cultured in a medium enriched with water from La Roche Posay.

Bacterial extracts cultured in thermal waters comprising anti-redness agents

Bags and/or dark circles around the eyes of individuals afflicted therewith are reduced by administering to such individuals thus effective amounts of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which includes at least one non-sulfurous mineral and/or thermal water, e.g., an extract derived from the bacterium, in particular the strain ATCC 15551, cultured in a medium enriched with water from La Roche Posay.

Bacterial extracts cultured in thermal waters for reducing bags and/or dark circles around the eyes

The invention relates to the nontherapeutic cosmetic use of at least one cannabinoid compound chosen from the compounds corresponding to general formula (I): and also the geometric isomers and optical isomers thereof, the cosmetically acceptable acid or base salts thereof, and the hydrates thereof;

Use of cannabinoid compounds for stimulating melanogenesis

The invention relates to a method of treating and preventing ageing of the pilosebaceous unit and/or alopecia in human through the administration of taurine and/or hypotaurine and/or the acceptable salts thereof in an oral composition. Specifically, the invention relates to a method of treating and preventing miniaturization of the hair follicle. The invention also relates to the use of polyphenols to achieve these same ends. Finally, the invention relates to oral compositions that include polyphenols or taurine and/or hypotaurine and/or the acceptable salts thereof as active ingredients.

Use of taurine for treating alopecia

Sensitive skin, mucous membranes and scalps are treated by administering to individuals in need of such treatment, thus effective amounts of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which includes at least one non-sulfurous mineral and/or thermal water, e.g., an extract derived from the bacterium, in particular the strain ATCC 15551, cultured in a medium enriched with water from La Roche Posay.

Bacterial extracts cultured in thermal waters for treating sensitive skin, mucous membranes and scalps

The present invention pertains to the use of probiotics for the preparation of a carrier for balancing the skin's immune function. In particular, the present invention pertains to the use of probiotic micro-organisms for balancing the skin's immune function under stress conditions, such as a exposure to ultraviolet radiation, specifically for enhancing the skin's immune activity and reducing the tendency to develop allergic reactions under such conditions.

Use of probiotic lactic acid bacteria for balancing the skin's immune system

The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing, whether chronobiologic or light-induced, and in particular skin ageing caused by decrease of skin elasticity and/or by collagen degradation in the structure of tissues.

Process for treating the skin comprising applying to the skin at least one composition comprising at least one N-aminoacylamide

A cosmetic or dermatological composition characterized in that it comprises an association between an elastase inhibitor compound of the N-acylaminoamide family and at least one metalloproteinase inhibiting compound.

Cosmetic or dermatological composition comprising an association between a compound of the N-acylaminoamide family and at least one matrix metalloproteinase inhibitor

The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing, whether chronobiologic or light-induced, and in particular skin ageing caused by decrease of skin elasticity and/or by collagen degradation in the structure for tissues.

Compounds of the N-acylamino amide family compositions comprising them and uses thereof

C-glycoside compounds are suited for stimulating the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue, advantageously hyaluronic acid, and/or proteoglycans, advantageously proteoglycans containing hyaluronic acid, by fibroblasts and/or keratinocytes.

C-glycoside compounds for stimulating the synthesis of glycosaminoglycans

Growing community of inventors

Versailles, France

Lionel Breton