Oregon State University

Inha-Industry Partnership Institute

Linquan Bai

Zixin Deng

David H Sherman

Hui Xu

Taifo Mahmud

Kyu B Han

Eung-Soo Kim

Jongtae Yang

Mi-Jin Lee

Shuangjun Lin

Dekun Kong

The present invention relates to a novel polyene compound similar to nystatin, a method for preparing the same, and an antifungal drug comprising the novel polyene compound as an active ingredient. Compared to nystatin comprising one sugar, NNP, which is the polyene compound similar to nystatin, displays 300 times higher solubility and ten times lower cytotoxicity while maintaining antifungal activity, and thus can be useful in developing a novel polyene antifungal agent having improved solubility and less toxicity in terms of pharmacokinetics.

Polyene compound, method for preparing the same, and antifungal drug comprising novel polyene compound as active ingredient

This disclosure relates to validamycin A biosynthesis and in particular, to methods of producing validamycin A analogs and uses thereof. In a particular example, a method for making a validamycin A analog includes transforming a host cell with one or more recombinant DNA vectors to produce a valN-inactivated mutant; and culturing the valN-inactivated mutant in a culture medium to produce a validamycin A analog, such as 1,1'-bis-valienamine and validienamycin, and their conversion to valienamine. The present disclosure further relates to compositions including such compounds as well as methods of using the compositions, such as for antifungal agents.

Methods of producing validamycin A analogs and uses thereof

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Shanghai, China

Linquan Bai