Arizona State University

Oncomyx Therapeutics, Inc.

Lino Torres-Dominguez

Douglas Grant McFadden

Mohammed Masmudur Rahman

Nancy Yaneth Villa

Leslie Lynne Sharp

Lina Franco Achury

Disclosed herein, in certain embodiments, are recombinant myxoma viruses (MYXVs) and nucleic acid constructs encoding the recombinant MYXVs. In some embodiments, the MYXVs are engineered to inactivate or attenuate an activity or expression level of an M153 protein. In some embodiments, the MYXVs are engineered to express one or more transgenes such as a tumor necrosis factor (TNF), interleukin-12 (IL-12), or decorin. Also disclosed herein, in certain embodiments, are methods of using the MYXVs. Some embodiments include providing a MYXV as described herein to a subject in need thereof.

Growing community of inventors

Tempe, AZ, United States of America

Lino Torres-Dominguez