Hitgen, Inc.

Chengdu Henghao Investment Co. Limited

Chengdu Henghao Innovative Science and Technology Co., Ltd.

Linli Li

Shengyong Yang

Wei Jun Zhang

Jin Li

Jinqiao Wan

Dengfeng Dou

Wei Zhang

Yan Lan

Xueming Li

Jingming Li

A phenothiazine ferroptosis inhibitor, a preparation method therefor and an application thereof. Specifically provided is a compound represented by formula I, or a salt thereof, or a stereoisomer thereof. The synthesized phenothiazine compound has a good inhibitory effect on ferroptosis and has good drug safety. Moreover, the compound can be used to prepare a ferroptosis inhibitor, and can also be used to prepare a drug for treating diseases related to ferroptosis, such as neurodegenerative diseases, tumors, tissue ischemia reperfusion injury, stroke, cardiovascular diseases, renal failure, and diabetic complications.

Phenothiazine ferroptosis inhibitor, preparation method therefor and application thereof

10H-phenothiazine derivatives capable of inhibiting ferroptosis has structural formula (I). The derivatives, pharmaceutically acceptable salts thereof, crystal forms thereof, or solvates thereof exhibit inhibitory effect on ferroptosis, and therapeutic effect on a rat model of focal cerebral ischemia and thus can be used as a main active ingredient in the preparation of ferroptosis inhibitors. The compounds and the inhibitors prepared by the compounds have good medicinal potential and are expected to be used as drug candidates for the treatment of stroke. 

10H-phenothiazine ferroptosis inhibitor as well as the preparative method and the use thereof

The present invention discloses a compound shown in formula I or a stereoisomer, pharmaceutically acceptable salt, crystal form, solvate or isotopologue thereof. The compound of the present invention shows excellent inhibition activity against histone deacetylases, has remarkable inhibition effects on cancer cells, and provides a new choice of drugs used for the clinic treatment and diseases related to the abnormal activity of histone deacetylases. 

Sulfamide derivatives and preparation method and use thereof

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Sichuan, China

Linli Li