The United States of America, As Represented by the Secretary, Department of Health and Human Services

Sun Yat-senuniversity

An, Linkun

Linkun An

Yves Pommier

Christophe Marchand

Compounds of Formula I and the pharmaceutically acceptable salts thereof are disclosed The variables X, X, and Rare disclosed herein. The compounds are useful for treating cancer and related proliferative diseases. Pharmaceutical compositions containing compounds of Formula I and methods of treatment comprising administering compounds of Formula I are also disclosed.

Furoquinolinediones as inhibitors of TDP2

Compounds of Formula I and the pharmaceutically acceptable salts thereof are disclosed Formula I. The variables X, X, and Rare disclosed herein. The compounds are useful for treating cancer and related proliferative diseases. Pharmaceutical compositions containing compounds of Formula I and methods of treatment comprising administering compounds of Formula I are also disclosed. 

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Guangzhou, China

Linkun An