Dow Agrosciences LLC

Wisconsin Alumni Research Foundation

Metabolon, Inc.

Other

Syngenta Participations Ag

Paradigm Genetics, Inc.

Lining Guo

Donald J Merlo

Scott A Young

Barry W Schafer

James K Petell

Kitisri Sukhapinda

Jean L Roberts

Ignacio Mario Larrinua

Scott Bevan

Jon Christopher Mitchell

Scott B Bintrim

Patricia C Apel-Birkhold

Jacob Wulff

Susan B Green

James A Strickland

Timothy Denver Hey

Otto Folkerts

Michael V Milburn

Matthew W Mitchell

Ann Owens Merlo

Rod Aaron Herman

Thomas A Rocheleau

David J Bowen

Jerald Coleman Ensign

Richard H Ffrench-Constant

Todd A Ciche

Gregory L Orr

Raymond Fatig

Sue Schoonover

Michael B Blackburn

James A McSwiggen

Nalini M Desai

John A Ryals

Kay A Lawton

Neil Madison Cowen

Robert Ascenzi

Katherine Armstrong

Beth C Rubin-Wilson

Jorn Gorlach

Carol M Hamilton

Douglas C Boyes

Adam D Kennedy

Neil E Hoffman

Keith R Davis

Adel Zayed

Jeffrey P Woessner

John W Rice

Jonathan Cohn

Thomas Skokut

Kateri Duncan

Rao Mulpuri

Bryan Wittmann

Daniel N Riggsbee

Joseph Cameron Mitchell

Susanne Kjemtrup

Brent E Edington

Andrea Eckhart

Michael G Zwick

Patricia Ann Owens Merlo

Thomas J Jönsson

Tom Skokut

Ryan Douglas Michalek

Jacob Edward Wulff

Methods are described herein for small molecule biochemical profiling of an individual subject for diagnosis of a disease or disorder, facilitating diagnosis of a disease or disorder, and/or identifying an increased risk of developing a disease or disorder in the individual subject. Aberrant levels of small molecules present in a sample from an individual subject are identified and diagnostic information relevant to the individual subject is obtained based on the identified aberrant levels. The obtained diagnostic information includes one or more of an identification of at least one biochemical pathway associated with the identified subset of the small molecules having aberrant levels, an identification at least one disease or disorder associated with the identified subset of the small molecules having aberrant levels, and an identification of at least one recommended follow up test associated with the identified subset of the small molecules having aberrant levels.

Small molecule biochemical profiling of individual subjects for disease diagnosis and health assessment

The present invention relates to the fields of agriculture, plant breeding or genetic engineering for plants with increased yield, crop forecasting and crop management. In particular, the methods herein describe novel methods of predicting a plant's yield through the measurement of specific metabolites either individually or in combination with one another in a specific plant reproductive tissue. The plant predictive methods described herein may be used to predict yield of plant populations as well as allow for more efficient crop management practices (e.g. amount and timing of chemical applications or amount of irrigation water applied to a field).

Methods of predicting crop yield using metabolic profiling

The present invention provides various biomarkers for hepatotoxicity and various methods of using the biomarkers Some of the biomarkers within the scope of this invention are cholate, glycochenodeoxycholate, glycocholate, taurine, 3-hyroxy-2-ethylpropionate, 4-imidazoleacetate, tyramine, anthranilate, 2'-deoxycytidine, N-acetyl aspartate (NAA), beta-hydroxy-hexanoate, and sarcosine (N-methylglycine) The methods of using the biomarkers include exposing a first hepatocyte culture to a test agent and comparing the levels of the one or more biomarkers obtained in the first hepatocyte culture to the levels of the one or more biomarkers obtained in a second hepatocyte culture without the test agent, where differential levels of the one or more biomarkers in the first hepatocyte culture as compared to the levels in the second hepatocyte culture is indicative of the test agent being a hepatotoxicant.

Determining liver toxicity of an agent using metabolite biomarkers

The subject invention relates to noveltoxin complex (TC) proteins and genes that encode these proteins. More specifically, the subject invention relates to TC genes and proteins obtainable fromstrain Xwi. The subject invention also provides an exochitinase obtainable from the Xwi strain. This exochitinase can be used to control insects using methods known in the art.

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Proteins from the genusare toxic to insects upon exposure.(formerly) have been found in mammalian clinical samples and as a bacterial symbiont of entomopathogenic nematodes of genus. These protein toxins can be applied to, or genetically engineered into, insect larvae food and plants for insect control.

Nucleic acid encoding an insecticidal protein toxin from photorhabdus

The subject invention relates to novel nucleic acid encoding astrain Xwi toxin complex (TC) protein and plants and bacteria transformed therewith.

The present inventors have discovered that serine acetyltransferase (SAT) is essential for plant growth. Specifically, the inhibition of SAT gene expression in plant seedlings results in reduced growth and altered pigmentation. Thus, SAT is useful as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of herbicides by measuring the activity of an SAT in the presence and absence of a compound, wherein an alteration of SAT activity in the presence of the compound indicates the compound as a candidate for a herbicide.

Methods for the identification of inhibitors of serine acetyltransferase activity in plants

Novel polynucleotide sequences that encode insect toxins TcdA and TcbA have base compositions that differ substantially from the native genes, making them more similar to plant genes. The new sequences are suitable for use for high expression in both monocots and dicots. Transgenic plants with a genome comprising the nucleic acid of SEQ ID NO:4 are insect resistant.

Transgenic plants expressing photorhabdus toxin

Novel polynucleotide sequences that encode insect toxins TcdA and TcbA have base compositions that differ substantially from the native genes, making them more similar to plant genes. The new sequences are suitable for use for high expression in both monocots and dicots. Transgenic plants with a genome comprising a nucleic acid of SEQ ID NO: 3 or SEQ ID NO:4 are insect resistant.

Proteins from the genus Photorhabdus are toxic to insects upon exposure. (formerly ) have been found in mammalian clinical samples and as a bacterial symbiont of entomopathogenic nematodes of genus Heterorhabditis. These protein toxins can be applied to, or genetically engineered into, insect larvae food and plants for insect control.

Insecticidal protein toxins from Photorhabdus

The present invention relates to nucleic acid molecules encoding delta 9 desaturase gene, and expression vectors, plant cells, and transgenic plants expressing delta 9 desaturase nucleic acid. The nucleic acid molecules of the present invention can be used, for example, to decrease delta 9 desaturase activity in plant cells, resulting in decreased unsaturated fatty acid production.

Nucleic acid encoding delta-9 desaturase

Genes encoding maize oleoyl-ACP and palmitoyl-ACP thioesterase enzymes have been isolated from maize. These genes, when expressed in a plant, can be used to create transgenic plants having altered palmitic acid oil profiles.

Acyl-ACP thioesterase nucleic acids from maize and methods of altering palmitic acid levels in transgenic plants therewith

Growing community of inventors

Chapel Hill, NC, United States of America

Lining Guo