Syngenta Crop Protection, Inc.

Syngenta Participations Ag

Syngenta Corporation

Linhua Wang

Ritesh Sheth

Fanny Giordano

Thomas Vettiger

Maren Fuerst

Juerg Wiss

Jefferson Thomas Ebert

Ritesh Bharat Sheth

Colin Ellis

Kristine Anderson Dolbeare

Frankie Lee Odom

The present invention provides a process for the preparation of a compound of formula I: wherein Ris C-Chaloalkyl;Ris optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; andRis methyl or ethyl;comprising reacting a compound of formula IV: wherein R, Rand Rare as defined for the compound of formula I;with an alkylating agent in the presence of an amide.

Process for the preparation of 3-haloalkylpyrazoles

The present invention provides a process for the preparation of a compound of formula (I) wherein Ris C-Chaloalkyl; Ris optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; and Ris methyl or ethyl; comprising reacting a compound of formula (IV) wherein R, Rand Rare as defined for the compound of formula I; with an alkylating agent in the presence of an amide. 

The invention provides a process for the preparation of a compound of formula (I) in particular, wherein a compound of formula (II) is reacted with a dialkylsulphate. Ris C-Chaloalkyl; Ris optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; and Ris methyl or ethyl. 

Processes for the alkylation of pyrazoles

The present invention relates to processes for the preparation of a compound of formula (I) comprising reacting a compound of formula (IV) with a compound of formula III or (IIIA) in the presence of an acid; wherein Ris C-Chaloalkyl; Ris optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; Ris methyl or ethyl; Ris hydrogen, optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; and n is 0 or 1. 

Processes relating to the alkylation of pyrazoles

A process for the production of a compound of formula (I), which comprises a) reacting a compound of formula (II), wherein Rand Rare both independently C-Calkyl, with methylhydrazine in the presence of water and a water-immiscible organic solvent being inert in saponification reactions, to form a compound of formula (III) wherein Ris as defined for formula (II) and b) saponifying that compound in situ leading to the formation of the compound of formula (I) by b1) adding a base to form the anion of the compound of formula (I) and then adding an; acid to form the compound of formula (I); or b2) adding an acid to form the compound of formula (I). 

Process for the production of pyrazoles

The present invention relates to a process for the production of compounds of formula (I) wherein X is fluoro, chloro, bromo or iodo and n is 1, 2, 3 or 4, which process comprises reacting a compound of formula (II) wherein the substituents are as defined for formula (I), with inorganic nitrite in an acidic aqueous medium in the presence of bromide and a copper catalyst and wherein the process is carried out as a one-pot reaction. 

Process for the production of substituted bromobenzenes

The present invention provides a process for the production of intermediate compounds of formula (I), wherein the substituents are as defined herein. The process comprises reacting a substituted aniline with aqueous HX, followed by removal of water by azeotropic distillation and diazotization and pyrolysis with an organic nitrite at elevated temperatures in the absence of a copper catalyst. Alternatively, gaseous HX can be used to substitute aqueous HX in the process. Consequently, a step of water removal by azeotropic distillation can be eliminated. The intermediate compounds of formula I are suitable as intermediates in the preparation of herbicidally active 3-hydroxy-4-aryl-5-oxopyrazoline derivatives. 

Growing community of inventors

Greensboro, NC, United States of America

Linhua Wang