Stowers Institute for Medical Research

University of Kansas-ku Medical Center Research Institute

Other

University of Chicago

University of Connecticut

Institute for Systems Biology

The Childrens' Mercy Hospital

Linheng Li

John M Perry

Xi C He

Justin C Grindley

Leroy E Hood

Weiguo Andy Tao

Anuradha Roy

Qiang Tian

Tong Yin

Chuan He

Scott J Weir

Xiuling Lu

Rajeswari Kasi

Gurusingham Sitta Sittampalam

Fang Tao

Tara Lin

Pengxu Qian

Aparna Venkatraman

Zhenrui Li

Nancy B Spinner

Ian D Krantz

The present invention relates to methods for expanding a stem cell population, as well as other cell populations. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell and/or other cell population, particularly a hematopoietic stem cell population.

Methods and compositions for expansion of cell population

The present disclosure provides, inter alia, methods for treating cancers including leukemia using low doses of an anthracycline such as doxorubicin.

Methods for overcoming WNT/beta-catenin anti-cancer resistance in leukemia stem cells

The disclosure provides methods of treating cancer by selectively inhibiting p-S-&#x3b2;-catenin, p-T-&#x3b2;-catenin, p-T-&#x3b2;-catenin, and/or p-S-&#x3b2;-catenin production and/or activity. Such methods also and/or limit cancer-initiating cells.

Methods for treating chemoresistant cancer-initiating cells

The present invention relates to methods and kits for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods, kits, and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.

Methods, kits, and compositions for stem cell self-renewal

Methods and kits for expanding a stem cell population, particularly a hematopoietic stem cell population, in the presence of a DNA methyltransferase modulator and a Wnt pathway modulator are disclosed.

The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.

Methods and compositions for stem cell self-renewal

The present invention relates to a purified molecules, including antibodies, that bind specifically to murine &#x3b2;-catenin phosphorylated at amino acid position Serineand to orthologs thereof, such as mammalian orthologs, including human orthologs. Methods of making and using such purified molecules are also provided. Kits containing such purified molecules are further provided.

Method of detecting phosphorylation state of beta-catenin

Antibodies that bind specifically to phosphorylated &#x3b2;-catenin

The present invention provides an isolated polypeptide exhibiting substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the polypeptide does not have the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. The invention further provides an isolated nucleic acid molecule containing a nucleotide sequence encoding substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the nucleotide sequence does not encode the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. Also provided herein is a method of inhibiting differentiation of hematopoietic progenitor cells by contacting the progenitor cells with an isolated JAGGED polypeptide, or active fragment thereof. The invention additionally provides a method of diagnosing Alagille Syndrome in an individual. The method consists of detecting an Alagille Syndrome disease-associated mutation linked to a JAGGED locus.

Methods of diagnosing alagille syndrome

Growing community of inventors

Kansas City, MO, United States of America

Linheng Li