University of California

Lingyun Cheng

William Freeman

Michael J Sailor

Yang Yang Li

Frederique Cunin

Emily Anglin

Karl Y Hostetler

William R Freeman

This invention relates to devices, systems and methods for delivering preprogrammed quantities of an active ingredient to a biological system over time without the need for external power or electronics.

Materials and methods for delivering compositions to selected tissues

A minimally invasive controlled drug delivery system for delivering a particular drug or drugs to a particular location of the eye, the system including a porous film template having pores configured and dimensioned to at least partially receive at least one drug therein, and wherein the template is dimensioned to be delivered into or onto the eye.

Porous photonic crystals for drug delivery to the eye

Methods are provided for treating pathological conditions of ocular tissue by administering to subjects in need thereof therapeutically active complexes that include amphiphilic analogs of the therapeutically active agents. These complexes exhibit low water solubility and are isolated in either crystalline form, amorphous form, or a combination thereof, within a well-defined particle size range. Administration of such complexes of therapeutically active agents to ocular tissue results in extended release of the therapeutically active agent. Indeed, certain complexes persist for up to about 20-30 weeks or longer after intravitreal injection, thereby providing a sustained release of therapeutically active agent into the structures of the eye.

Lipid-drug conjugates for local therapy of eye diseases

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San Diego, CA, United States of America

Lingyun Cheng