Shanghai Shengdi Pharmaceutical Co., Ltd

Shanghai Senhui Medicine Co., Ltd.

Jiangsu Hengrui Medicine Company Ltd.

Jiangsu Hengrui Pharmaceuticals Co., Ltd.

Lingjian Zhu

Jian Huang

Wei Jiang

Weicou Cao

Xiuzhao Yu

Yang Zou

Yinggang Tang

Piaoyang Sun

The present invention relates to a sulfonylurea derivative and medical uses thereof, specifically relating to the sulfonylurea derivative shown in general formula (I), a preparation method thereof, a pharmaceutical composition containing same, and a use of same for treating diseases and disorders affected by neuronal damage, for example: cerebral stroke, brain damage, neuropathic pain, migraines, inflammatory pain, chronic pain, or depression. The definition of each group in the general formula (I) is the same as that in the description.

Sulfonylurea derivative and medical uses thereof

The present invention relates to an echinocandin analogue and a preparation method therefor. The compound can be used for preventing or treating fungal infection, or for preventing, stabilizing or inhibiting fungal growth or killing fungi. An exemplary compound is represented by formula I, wherein the definitions of R, R, Rand G groups are as described in the description.

Echinocandin analogues and preparation method therefor

A compound represented by formula II or a pharmaceutically acceptable salt thereof, and a preparation method therefor. The compound represented by formula II is an antagonist of a neurokinin-1 receptor, can be used for treating diseases related to the neurokinin-1 receptor, and can avoid hemolytic effects of drugs and reduce the side effects of drug administration.

Neurokinin-1 antagonist

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Shanghai, China

Lingjian Zhu