Jiangsu Hengrui Medicine Company Ltd.

Shanghai Shengdi Pharmaceutical Co., Ltd

Shanghai Senhui Medicine Co., Ltd.

Lingjian Zhu

Jian Huang

Wei Jiang

Yinggang Tang

Yang Zou

Weicou Cao

The present invention relates to an echinocandin analogue and a preparation method therefor. The compound can be used for preventing or treating fungal infection, or for preventing, stabilizing or inhibiting fungal growth or killing fungi. An exemplary compound is represented by formula I, wherein the definitions of R, R, Rand G groups are as described in the description.

Echinocandin analogues and preparation method therefor

A compound represented by formula II or a pharmaceutically acceptable salt thereof, and a preparation method therefor. The compound represented by formula II is an antagonist of a neurokinin-1 receptor, can be used for treating diseases related to the neurokinin-1 receptor, and can avoid hemolytic effects of drugs and reduce the side effects of drug administration.

Neurokinin-1 antagonist

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Shanghai, China

Lingjian Zhu