Other

Nuvelo, Inc.

Variagenics, Inc.

Ling X Shen

Gregory Lawrence Verdine

Vincent P Stanton, Jr

James P Basilion

Described are methods for identifying targets in RNA molecules based on differences in RNA secondary structure related to sequence variances between different allelic forms. Also described are methods for identifying or developing small molecules which can be used to modulate a target RNA by creation of protein-small-molecule-RNA complexes, as well as compositions which include such small molecules and methods of using those small molecules and compositions.

Methods for targeting RNA molecules

Methods are described for identifying an RNA target for an allele-specific RNA inhibitor by identifying a sequence variance in an RNA encoded by a gene of interest, and determining whether the secondary structure of the RNA comprising the variance differs from that of an otherwise identical RNA not comprising the variance.

Growing community of inventors

Marlboro, MA, United States of America

Ling X Shen