Shanghai Institute of Pharmaceutical Industry

Les Laboratoires Servier

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd.

Ling Tong

Zhedong Yuan

Xiong Yu

Yu Huang

Hanbin Shan

Xueyan Zhu

Xingdong Cheng

Wenliang Zhou

Yulei Yang

Laifang Zhang

The present invention provides a new crystalline form VII of agomelatine, its method of preparation, application and pharmaceutical composition. This new crystalline form offers high purity, a stable crystalline structure and good reproducibility, while its method of production lends itself well to large scale production. In terms of stability and purity, it is superior to the numerous crystalline forms which have hitherto been reported. As a result, the crystalline form VII of the present invention possesses advantages in pharmaceutical preparation.

Crystal form VII of agomelatine, preparation method and use thereof and pharmaceutical composition containing same

The present application discloses crystals of 2-acetoxy-5-(&#x3b1;-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrobromate, crystal compositions and pharmaceutical compositions comprising them and their use. The crystals of prasugrel hydrobromate of the present application possess excellent stability and solubility.

Crystals of prasugrel hydrobromate

Growing community of inventors

Dongguan, China

Ling Tong