International Business Machines Corporation

Jiangsu Hengrui Medicine Company Ltd.

Shanghai Hengrui Pharmaceutical Co., Ltd.

Huawei Technologies Co., Limited

Inventec Appliances Corporation

Shanghai Xpt Technology Limited

Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Jiangsu Hengrui Pharmaceuticals Co., Ltd.

Suzhou Jufeng Electrical Insulation System Co., Ltd.

Ling L Zhang

Weikang Tao

Fanglong Yang

Xiao Feng Yu

Hai Bin Dai

Feng He

Heng Chu

Lianshan Zhang

Yayuan Fu

Dongbing Cui

Jiajian Liu

Yongfeng Zhong

Chunfei Wang

Ting Yong Zhu

Peng Hui Jiang

Qing Dong

Si Bin Fan

Yan Xu

Jia Zou

Piaoyang Sun

Michael Baessler

Yang Wayne Wang

Ying Zhang

Zhen Zhang

Qiyue Hu

Ying Shen

Tony Tsai

David Ho

Xian Li

Hua Ying

Yali Wang

Hu Ge

Yu Xia

Mingxun He

Guangyuan Shen

Yifang Wang

Cheng Zhou

Lu Bi

Jindong Liang

Liangliang Zheng

Jianyan Xu

Guiyang Jiang

Guo Li

Jingping Wei

Haoying Zhang

Jihui Han

Shen Yu

Ge Qin

Yanjun Cai

Xingwu Dai

Dong Ma

Qingquan Lei

Xiaoying Yang

Junzhuan Qiu

Ziyong Sun

Jiping Zha

The present disclosure relates to a CD3 antibody and a pharmaceutical use thereof. Specifically, the present disclosure relates to forming a multi-specificity antibody by using CD3 antibody and binding molecules of another target. The multi-specificity antibody may simultaneously bind to CD3 and another tumor-associated antigen, and bind and activate CD3-positive T cells while binding tumor-associated antigen-expressing cells, thereby promoting T cells specifically killing tumor cells that express tumor-associated antigens. In addition, the present disclosure also provides a preparation and application of a multi-specific antibody.

CD3 antibody and pharmaceutical use thereof

Disclosed are fused imidazole derivatives, preparation methods therefor and medical uses thereof. Specifically, the present disclosure relates to a fused imidazole derivative as shown in general formula (IM), a preparation method therefor, a pharmaceutical composition containing the derivative, and the use of same as a therapeutic agent, in particular the use thereof as a GLP-1 receptor agonist, and the use thereof in the preparation of drugs for the treatment and/or prevention of diabetes.

Fused imidazole derivative, preparation method therefor, and medical use thereof

A corona-resistant enameled round wire and preparation method of making such which is suitable for electric vehicle motors and has a copper conductor and an insulating layer. The insulating layer clads the copper conductor and has in sequence from inside to outside, a corona- resistant polyamideimide coating, a corona-resistant special resin coating, a corona-resistant polyimide coating, a corona-resistant modified silicone resin coating, and a corona-resistant polyamideimide coating.

Corona-resistant enameled round wire and preparation method therefor

The present invention generally relates to computer security, and more specifically, related to registration and authorization cross multiple domains. In an aspect, a computer-implemented method, computer-implemented system, and computer program product for cross domain registration by a source domain is provided. A request is sent by a source domain to register the source domain as a trusted domain of a target domain. An approval of the request is received by the source domain. The source domain issues a key to an application of the source domain for accessing the target domain.

Key-based cross domain registration and authorization

A server or other computing device can receive a request for a feed (e.g., Really Simple Syndication, Atom, or other Extensible Markup Language format feed) from a client. Content of the requested feed and a type of the client can be determined. Executable processing logic can be added into the requested feed according to the determined content of the feed and the type of the client. The feed into which the executable processing logic has been added can be sent to the client.

Sending and requesting feed

The present invention relates to a 3,4-bipyridyl pyrazole derivative, and a preparation method therefor and a medical application thereof. Specifically, the present invention relates to a new 3,4-bipyridyl pyrazole derivative as shown in formula (I), a preparation method for the derivative, a pharmaceutical composition containing the derivative, a use of the derivative as a therapeutic agent, in particular as a TGF-&#x3b2; inhibitor, and a use of the derivative in the preparation of a drug which treats, prevents or reduces cancer mediated by TGF-&#x3b2; overexpression. The substituents in formula (I) have the same definitions as in the description. 

3,4-bipyridyl pyrazole derivative, and preparation method therefor and medical application thereof

A data caching method and device, and a resource request response method and device. The data caching method comprise: receiving a resource request for group content belonging to a specific user group, the resource request being sent from a user terminal to an application server by a user; checking if a mapping between the group content and a group caching ID for identifying the user group and a mapping between the user and the group caching ID have been established in the caching server; and returning the group content cached in the caching server to the user terminal in responses to the mapping between the group content and the group caching ID and the mapping between the user and the group caching ID having been established in the caching server.

Data caching and resource request response

Provided are an anti-c-Met antibody or an antigen binding fragment thereof, and an anti-c-Met antibody-cytotoxic drug conjugate, wherein the antibody or antigen binding fragment thereof is a chimeric antibody or a humanized antibody. Also provided are pharmaceutical compositions containing the humanized anti-c-Met antibody or antigen binding fragment thereof, the antibody-cytotoxic drug conjugate, or pharmaceutically acceptable salts or solvents thereof, that are used in the treatment of cancer.

Anti-c-Met antibody and anti-c-Met antibody-cytotoxic drug conjugate and pharmaceutical use thereof

Provided is a humanized antibody and chimeric antibody that specifically binds human sclerostin. The antibodies can be used for treating human bone metabolism related diseases such as osteoporosis (OP).

Anti-sclerostin antibody, antigen binding fragment and medical use thereof

The present invention relates to a benzopiperidine derivative, a preparation method thereof and a medical use thereof. In particular, the present invention relates to a benzopiperidine derivative as shown by general formula (I), a preparation method thereof and a pharmaceutical composition containing the derivative, as well as a use thereof as an estrogen receptor modulator in the prevention and/or treatment of estrogen receptor-mediated or dependent diseases or conditions. Preferably, the disease is breast cancer. The substituents in the general formula (I) are the same as those defined in the description. 

Benzopiperidine derivative, preparation method thereof and medical use thereof

Embodiments of the present invention may share common data among multiple servers. According to one embodiment of the present invention, a code segment is obtained at a first server from a client in response to the client interacting with a first application hosted on the first server, where the code segment is associated with business logic in the first application. Then, the first application is executed based on the code segment.

Business logic sharing

Data sharing

Growing community of inventors

Shanghai, China

Ling L Zhang