Ribomic Inc.

Fujimoto Pharmaceutical Corporation

Otsuka Pharmaceutical Company, Limited

Veritas in Silico Inc.

Ling Jin

Yoshikazu Nakamura

Hisanao Hiramatsu

Masatoshi Fujiwara

Takashi Kamimura

Shin Miyakawa

Shingo Nakamura

Satoko Yamazaki

Masahiro Muraguchi

Amiu Shino

Hisako Ikeda

A method for screening for a compound capable of modulating gene expression by calculating an existence probability of a local secondary structure that may exist in a target RNA sequence; selecting a local secondary structure with the desired existence probability; preparing a screening probe corresponding to the selected local secondary structure; and screening for the compound using the probe.

Method for screening compound for controlling RNA function

Provided are an aptamer having an inhibitory activity against NGF; a complex containing an aptamer having a binding activity or inhibitory activity against NGF and a functional substance (e.g., affinity substances, labeling substances, enzymes, drug delivery vehicles, drugs and the like); a medicament, a diagnostic agent, a labeling agent and the like containing an aptamer having a binding activity or inhibitory activity against NGF, or a complex containing the aptamer and the functional substance; and the like.

Aptamer for NGF and use thereof

Provided by the present invention are an aptamer having an inhibitory activity on FGF2; a complex containing an aptamer having a binding activity or an inhibitory activity on FGF2, and a functional substance (e.g., affinity substance, labeling substance, enzyme, drug delivery vehicle, or drug and the like); a medicament, diagnostic reagent or labeling agent containing an aptamer having a binding activity or an inhibitory activity on FGF2, or a complex containing said aptamer and a functional substance; and the like.

Aptamer for FGF2 and use thereof

The present invention provides an aptamer binding to NGF and capable of forming a potential secondary structure represented by the formula (I): wherein N is one nucleotide selected from the group consisting of A, G, C, U and T,

NGF aptamer and application thereof

Provided is a higher quality aptamer having a binding activity to NGF. An aptamer binding to NGF, which satisfies the following (1) and (2):

Provided are an aptamer bound to chymase to inhibit activity of chymase; an aptamer containing a nucleotide sequence represented by XGAUAGANNUAAXwherein Xand Xare the same or different and each is A or G, and Nand Nare the same or different and each is A, G, C, U or T; a complex containing the aptamer and a functional substance (e.g., affinity substance, labeling substance, enzyme, drug delivery medium, drug and the like); a pharmaceutical or a reagent containing the aptamer or complex; a detection and a purification methods of chymase using the aptamer or complex and the like.

Growing community of inventors

Tokyo, Japan

Ling Jin