Rutgers, the State University of New Jersey

Aphios Corporation

Ling Chu

Trevor Percival Castor

Henrik Pederson

Henrik Pedersen

The present application features methods and apparatus for making liposomes containing hydrophobic drugs, with critical, supercritical or near critical fluids. The methods and apparatus combine a phospholipid, a drug, and an aqueous phase, or multilamellar vesicles, with a critical, supercritical or near critical fluid. Upon a reduction in pressure, liposomes are formed.

Methods and apparatus for making liposomes containing hydrophobic drugs

This invention provides for a fiber optic moisture sensor. The sensor is comprised of a housing and a support positioned within the housing. The support is coated with a film. A first and second light guides are positioned within the housing and communicate illumination to and from the film. A reflective surface is positioned within the housing facing the film. The film comprises an optically transparent polymer and a salt complex of a metal ion and an organic compound. The salt complex is capable of absorbing moisture and emits a fluorescence signal when excited by light at the appropriate wavelength. The fluorescence signal can be quenched when the salt complex absorbs moisture. An apparatus incorporating the sensor and a method of making the sensor are also provided.

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Chelmsford, MA, United States of America

Ling Chu