Institut Pasteur De Lille

Centre National De La Recherche Scientifique

Centre National De La Recherche Scientifique-cnrs

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Oleg Melnyk

Dominique Bonnet

Helene Gras-Masse

Hélène Gras-Masse

Jean-Sebastien Fruchart

The invention relates to a functionalised solid support for the synthesis of compounds comprising at least one &#x3b1;-oxoaldehyde function, to a process for preparing it and to its applications, in particular for the preparation of a library of organic compounds, of a diagnostic reagent, of a microtitration plate and of a biochip, such as a DNA chip. The present invention also relates to a process for the synthesis of organic compounds comprising at least one &#x3b1;-oxoaldehyde function and to the &#x3b1;-oxoaldehyde peptides obtained using this process.

Functionalised solid support for alpha-oxoaldehyde synthesis

The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, the coupling comprising a step which consists in producing a hydrazone bond between the peptide compound and the lipophilic vector. The invention also concerns lipophilic vectors for use in this method, lipopeptides obtained by this method, uses of the lipopeptides for cell screening, and the applications of the invention, in particular for preparing targeting of an active principle of the peptide kind (for example hormone or neuropeptide) through physiological barriers such as cell membranes.

Method for binding, in solution, a peptide and a lipophilic vector and uses thereof

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Lille, France

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