Cook Medical Technologies LLC

Angiotech Pharmaceuticals, Inc.

Other

Ikomed Technologies, Inc.

Angiogenesis Technologies, Inc.

Merit Medical Systems, Inc.

The University of British Columbia

Lindsay Stuart Machan

William L Hunter

A Larry Arsenault

John K Jackson

Kevin Letchford

Daniel Gelbart

Gregory R McArthur

Helen M Burt

Stephen K Dordunoo

John J Jackson

Larry A Arsenault

Various aspects of the present invention provide compositions and implantable devices including a water-insoluble therapeutic agent solubilized in a matrix of a gallate-containing compound. Other aspects provide methods of manufacturing and using such compositions and devices.

Compositions and devices incorporating water-insoluble therapeutic agents and methods of the use thereof

A movable mixing disc may be utilized in connection with a syringe. The mixing disc may comprise a hole which may be covered by a fine screen or coupled to a porous member, allowing only certain elements of a solution to pass through the mixing disc. Actuation of a plunger of the syringe may cause liquid to emerge from the mixing disc hole as a high velocity jet or other turbulent flow, stirring up any settled particles on a distal side of the mixing disc. As the ejection continues, the mixing disc may be pushed forward by the plunger in order to eliminate any unused volume. Also, the mixing disc may be moved forward by virtue of a pressure difference created by a pressure drop across the mixing disc, such as a pressure drop created as the plunger is displaced to induce fluid flow across the mixing disc.

Mixing syringe

Various aspects of the present invention provide compositions and implantable devices including a water-insoluble therapeutic agent solubilized in a matrix of a gallate-containing compound. Other aspects provide methods of manufacturing and using such compositions and devices

A lithotripsy system capable of 3D tracking monitors the acoustic reflection from the stone in order to focus the shock wave on the stone regardless of shock wave displacement or stone movement. The tracking and focusing is based on a phased array concept, allowing the lithotripsy head to remain stationary and well coupled to the body. An alternate shock wave steering is based on refraction by a variable liquid wedge.

Lithotripsy system with automatic 3D tracking

A movable mixing disc is inserted into a regular syringe. The mixing disc has a small hole covered by a fine screen, allowing only saline solution to get behind the disc. When the plunger of the syringe is pressed, the saline solution emerges from the mixing disc hole as a high velocity jet, stirring up the settled particles. As the ejection continues, the mixing disc is pushed forward by the plunger in order to eliminate any unused volume.

To reduce X-ray exposure while improving image quality, an area of interest is selected in the image. The image of the selected area is updated frequently, comparable to a rate of updates used today for the whole image. The rest of the image is updated at a significantly lower rate. Since the area of interest normally is a small part of the overall area, the total exposure is reduced significantly. A fast X-ray shutter, placed near the X-ray source, blocks the radiation from areas outside the area of interest. The shutter automatically retracts when the complete image is updated. The area of interest can be selected by the user or automatically selected based on activity in the image. Since most of the exposures are taken at a reduced collimation angle, limited by the area of interest, the area of interest is imaged at reduced scatter and better quality.

X-ray system

The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.

Anti-angiogenic nanoparticle compositions

To reduce X-ray exposure, an area of interest is selected in the image. The image of the selected area is updated frequently, comparable to rate of updates used today for the whole image. The rest of the image is updated at a significantly lower rate. Since the area of interest normally is a small part of the overall area, the total exposure is reduced significantly. A movable X-ray shield placed near the X-ray source blocks the radiation from areas outside the area of interest. The shield automatically retracts when the complete image is updated. The area of interest can be selected by the user or automatically selected based on activity in the image.

System for reduction of exposure to X-ray radiation

The present invention is directed to a stent comprising

Anti-angiogenic compositions and methods of use

The present invention provides methods for treating or preventing diseases associated with body passageways, comprising the step of delivering to an external portion of the body passageway a therapeutic agent. Representative examples of therapeutic agents include anti-angiogenic factors, anti-proliferative agents, anti-inflammatory agents, and antibiotics.

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Vancouver, Canada

Lindsay Stuart Machan