Serenex, Inc.

Esanex, Inc.

Lindsay A Hinkley

Gunnar J Hanson

James Marvin Veal

Thomas E Barta

Kenneth He Huang

Jeron Eaves

Lifeng Geng

Steven E Hall

Roy Wendell Ware

Matthew G Jenks

Klass P Hardeman

Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R, R, R, R, R, R, R, n, Q, Q, Q, Y, and X-Xare as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

Benzene, pyridine, and pyridazine derivatives

Alkyl-linked nucleotide non-homogeneous solid supports and nucleotide affinity media comprising an alkyl-linked nucleotide are provided. The linker is generally a hydrophobic linker that can be a 3, 4, 5, 6, 7, 8, 9, 10, or a longer carbon chain. Also included in the invention are methods for synthesis of an alkyl-linked nucleotide, nucleotide affinity media and methods of use thereof for affinity chromatography and screening methods.

Alkyl-linked nucleotide compositions

Growing community of inventors

Raleigh, NC, United States of America

Lindsay A Hinkley