89Bio, Inc.

Cephalon, Inc.

Linda Weinberg

Bruce D Dorsey

Robert L Hudkins

Allison L Zulli

Koc-Kan Ho

Gregory J Wells

Tao Guo

Craig A Zificsak

Nadine C Becknell

Dimitar B Gotchev

Reddeppa Reddy Dandu

Jay P Theroff

Karen L Milkiewicz

Sankar Chatterjee

Henry Joseph Breslin

Kurt A Josef

Gregory R Ott

Rabindranath Tripathy

James L Diebold

Derek D Dunn

Diane E Gingrich

Keith S Learn

Benjamin J Dugan

Greg A Hostetler

Eugen F Mesaros

Theodore L Underiner

Joseph Lisko

Gulzar Ahmed

Douglas A Pippin

Babu G Sundar

Jason C Wagner

Matthew A Curry

Tho V Thieu

Rong-qiang Liu

Ted Underiner

Jason Burke

Daming Feng

Ming You

Rachael Hunter

Adolph Bohnstedt

Joseph G Lisko

Jonathan Parrish

Rong-Qiang Liu

Karen Milkiewicz

Bruce Dorsey

Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds. Also described herein are methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

Substituted 4-benzyl and 4-benzoyl piperidine derivates

Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

1,4-substituted piperidine derivatives

Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds. Also described herein are methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses. 

Substituted 4-benzyl and 4-benzoyl piperidine derivatives

Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses. 

The present invention provides a compound of formula I or a salt form thereof, wherein Q, Q, Q, and Qare as defined herein. The compound of formula I has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.

Pyrrolotriazines as ALK and JAK2 inhibitors

The present invention provides a compound of Formula I or a pharmaceutically acceptable salt form thereof, wherein A, L, R, R, R, R, R, R, and X are as defined herein. The compounds of Formula I have ALK and/or c-Met inhibitory activity, and may be used to treat ALK- or c-Met-mediated disorders or conditions.

Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors

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King of Prussia, PA, United States of America

Linda Weinberg