Immunex Corporation

Linda S Park

David J Cosman

M Patricia Beckmann

Carl J March

Bruce A Mosley

Rejean Idzerda

Raymond G Goodwin

Benson M Curtis

Methods and comnositions related to antibodies that bind to mammalian Tnterleulcin-4 recentor proteins are disclosed.

Antibodies to Interleukin-4 receptors and uses thereof

Mammalian Interleukin-4 receptor proteins, DNAs and expression vectors encoding mammalian IL-4 receptors, and processes for producing mammalian IL-4 receptors as products of cell culture, are disclosed. A method for suppressing an IL-4-dependent immune or inflammatory response in a mammal, including a human, by administering an effective amount of soluble IL-4 receptor (sIL-4R) and a suitable diluent or carrier.

Antibodies to interleukin-4 receptors and uses thereof

Interleukin-4 receptors

DNA encoding interleukin-4 receptors

Mammalian Interleukin-4 receptor proteins find use in inhibiting biological activities of IL-4. A method for suppressing an IL-4-dependent immune or inflammatory response in a mammal, including a human, by administering an effective amount of soluble IL-4 receptor (sIL-4R) and a suitable diluent or carrier.

Use of interleukin-4 receptors to inhibit biological responses mediated

Mammalian antibodies that are immunoreactive with Interleukin-4 receptor proteins, DNAs and expression vectors encoding mammalian IL-4 receptors, and processes for producing mammalian IL-4 receptors as products of cell culture, as well as antibodies that are immunoreactive with IL-4 receptors. A method for suppressing an IL-4-dependent immune or inflammatory response in a mammal, including a human, involves administering an effective amount of soluble IL-4 receptor (sIL-4R) and a suitable diluent or carrier.

Antibodies that are immunoreactive with interleukin-4 receptors

Mammalian Interleukin-7 receptor proteins, DNAs and expression vectors encoding mammalian IL-7 receptors, antibodies to mammalian Interleukin 7 receptors and processes for producing mammalian IL-7 receptors as products of recombinant cell culture, are disclosed.

Antibodies to interleuken-7 receptors

Ligand reagents are disclosed which consist essentially of recombinant hyperglycosylated cytokines, expressed in yeast, which are purified and conjugated to various functional moieties, for example, biotin groups, via oligosaccharide residues. Methods of using such ligand reagents are also disclosed.

Hyperglycosylated cytokine conjugates

Mammalian Interleukin-7 receptor proteins, DNAs and expression vectors encoding mammalian IL-7 receptors, and processes for producing mammalian IL-7 receptors as products of recombinant cell culture, are disclosed.

Interleukin-7 receptors

Ligand reagents are disclosed which consist essentially of recombinant hyperglycosylated cytokines, expressed in yeast, which are purified and conjugated to various functional moieties, for example, biotin groups, via oligosaccharide residues.

DNA encoding interleukin-7 receptors and methods of use

A DNA sequence encoding fusion protein is disclosed which comprises GM-CSF and IL-3. Such fusion proteins more biologically active than GM-CSF or IL-3 alone or GM-CSF and IL-3 combined.

Growing community of inventors

Seattle, WA, United States of America

Linda S Park