Xoma Technology Ltd.

Novartis Ag

Schering Corporation

Xoma (US) LLC

Xoma Techolology Ltd.

Xoma Corporation

Linda Masat

Marina Roell

Gang Chen

Arnold H Horwitz

Mary Haak-Frendscho

Jeff Hsu

Daniel H Bedinger

Amer M Mirza

Siew Ho Schleyer

Mohammad Luqman

Jason Damiano

Masahisa Handa

Genevieve Nonet

Judy Abraham

Toshihiko Takeuchi

Sumant Ramachandra

Chin-Yi Huang

Chao Bai Huang

Walter Robert Bishop

Ssucheng Jeff Hsu

Seema Kantak

Siew Scheyer

EphB3-specific antibodies are provided, along with pharmaceutical compositions containing such antibody, kits containing a pharmaceutical composition, and methods of preventing and treating an EphB3-related disease or disorder.

Antagonist antibodies against EphB3

An IL-1&#x3b2; binding antibody or IL-1&#x3b2; binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL-1&#x3b2; binding polypeptide. IL-1&#x3b2; binding antibodies or IL-1&#x3b2; binding fragments thereof are provided which have desirable affinity and potency.

Pharmaceutical compositions comprising IL-1B binding antibodies and fragments thereof

EphB3-specific antibodies are provided, along with pharmaceutical compositions containing such antibody, kits containing a pharmaceutical composition, and methods of preventing and treating cancer.

EPHB3-specific antibody and uses thereof

PRLR-specific antibodies are provided, along with pharmaceutical compositions containing such antibody, kits containing a pharmaceutical composition, and methods of preventing and treating cancer.

PRLR-specific antibody and uses thereof

Antagonist antibodies against EPHB3

Method of treating inflammatory eye disease with IL-1&#x3b2; binding antibodies

The present invention relates to materials and methods for human antibodies specific for the peptide hormone gastrin and uses of these antibodies in the treatment of subjects having cancer and other conditions or disorders related to gastrin expression.

Human antibodies specific for gastrin materials and methods

Disclosed herein are fully human antibodies and antigen-binding fragments thereof that specifically bind human VEGF and inhibit VEGF binding to VEGF-R1 and VEGF-R2, and therefore inhibit VEGF signaling. The antibodies and antigen-binding fragments disclosed herein may be used, for example, to treat angiogenesis and conditions associated with angiogenesis both in vivo and in vitro.

Fully human anti-VEGF antibodies and methods of using

Method of treating an IL-1 related coronary condition

IL-1&#x3b2; binding antibodies and fragments thereof

Methods of treating or preventing an IL-1 related disease or condition in a mammal comprising administering an effective amount of an IL-1&#x3b2; binding antibody or IL-1&#x3b2; binding fragment thereof. An IL-1&#x3b2; binding antibody or IL-1&#x3b2; binding fragment thereof is provided comprising the amino acid sequence of SEQ ID NO: 15 and SEQ ID NO: 11, and related nucleic acids, vectors, cells, and compositions, and a method of preparing an affinity matured IL-1&#x3b2; binding polypeptide. IL-1&#x3b2; binding antibodies or IL-1&#x3b2; binding fragments thereof are provided which have desirable affinity and potency.

Method of treating an IL-1 related autoimmune disease or condition

Method of treating an IL-1 related cancer

Growing community of inventors

Walnut Creek, CA, United States of America

Linda Masat