Syntex (u.s.a.) Inc.

Other

Linda Marie Fish

Lakshmi Sangameswaran

Stephen Gregory Delgado

Ronald Herman

Douglas Kenneth Rabert

Paul Shartzer Dietrich

Ronald Charles Herman

The present invention relates to a voltage-gated sodium channel present in peripheral nerve tissue that is tetrodotoxin-resistant. One aspect of the present invention is purified and isolated DNA encoding this sodium channel. Another aspect of the present invention is the recombinant protein expressed by this DNA, expression vectors comprising the DNA sequence, and host cells transformed with these expression vectors. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-resistant sodium channel as a therapeutic target for compounds to treat disorders of the peripheral nervous system.

Method of modulating tetrotodoxin-resistant sodium channel

Human peripheral nerve, tetrodotoxin-resistant sodium channel &agr;-subunit polypeptide

DNA encoding for a voltage-gated, TTX-sensitive sodium channel is isolated. Also disclosed are polypeptide products of recombinant expression of these DNA sequences, expression vectors comprising the DNA sequences, and host cells transformed with these expression vectors. Other aspects of this invention are peptides whose sequences are based on the amino acid sequences deduced from these DNA sequences, antibodies specific for such proteins and peptides, procedures for detection and quantitation of such proteins, and nucleic acids related thereto. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-sensitive sodium channel as a therapeutic target for compounds.

Cloned tetrodotoxin-sensitive sodium channel &agr;-subunit and a splice variant thereof

Cloned peripheral nerve, tetrodotoxin-resistant sodium channel &agr;-subunit

Cloned tetrodotoxin-sensitive sodium channel .alpha.-subunit and a

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La Honda, CA, United States of America

Linda Marie Fish