Alza Corporation

Linda E Atkinson

Robert M Gale

Diane E Nedberge

Jeri D Wright

Patrick S Wong

Brian L Barclay

Jerry D Childers

David L Rivera

John T Dunn

Brian L Barcley

An osmotic device is disclosed comprising an exterior coat comprising an estrogenic and a progestogenic steroid that are delivered immediately as a contraceptive pair for fertility regulation in a female, and a compartment comprising an estrogenic steroid that is delivered at a controlled rate over a prolonged period of time for fertility regulation in a female.

Method for controlling fertility

A process is disclosed and claimed for preparing a therapeutic composition comprising asteroid or a dosage form comprising the composition, which therapeutic composition or dosage form is indicated for human administration.

Process for providing therapeutic composition

The present invention provides compositions and methods for the transdermal administration of a contraceptively effective amount of gestodene and estrogen, such as ethinyl estradiol, in combination, together with a suitable permeation enhancer. The amount of the estrogen codelivered is kept at an about constant and contraceptively effective rate while the amount of gestogen codelivered varies depending on the phase of the menstrual cycle but remains at a contraceptively effective rate. The size of the system may also vary depending on the amount of gestogeno be delivered.

Transdermal contraceptive formulations methods and devices

Diffusional delivery devices are constructed in two or more compartments, each containing a separate drug or other beneficial agent, and each arranged to permit diffusion of the agent out of the device through an individually-characterized agent-permeable wall segment. The diffusion rates of the various agents relative to one another are set and controlled by the parameters of the individual wall segments, such as the surface area of the wall segment, the average thickness of the wall segment, and the permeability of the wall segment for the particular agent. The permeability may be varied by variations in the chemical composition of the wall segment. Using these parameters rather than blending the agents at calculated ratios in a single formulation for diffusion through a single wall permits a wider range of, and greater flexibility in, variation between the diffusion rates of the different agents. This is of value when the simultaneous administration of agents at a specified ratio is desired.

Segmented device for simultaneous delivery of multiple beneficial agents

The present invention provides compositions and methods for the transdermal administration of a contraceptively effective amount of gestodene and an estrogen, such as ethinyl estradiol, in combination, together with a suitable permeation enhancer.

Transdermal contraceptive formulations, methods and devices

The present invention provides compositions and methods for the transdermal administration of a therapeutically effective amount of a synthetic 19-nor-progesterone (ST-1435) together with, optionally, a suitable permeation enhancer.

Transdermal delivery of the gestogen ST-1435 and devices therefor

The present invention provides compositions and methods for the transdermal administration of a therapeutically effective amount of a synthetic 19-nor-progesterone (ST-1435) and an estrogen, in combination, together with, optionally, a suitable permeation enhancer.

Transdermal formulations, methods and devices

Contraceptive pill

The present invention provides compositions and methods for the transdermal administration of a contraceptively effective amount of a synthetic 19-nor-progesterone (ST-1435) and an estrogen, in combination, together with a suitable permeation enhancer.

Osmotic, oral dosage form for fertility control

An osmotic device is disclosed comprising an estrogenic and a progestogenic steroid that are delivered as a contraceptive pair for fertility regulation in a female.

Growing community of inventors

Portola Valley, CA, United States of America

Linda E Atkinson