Glaxo Group Limited

Linda Carey

John W Clitherow

John Bradshaw

Barry J Price

Roger Hayes

David E Bays

John W MacKinnon

Duncan B Judd

Michael Martin-Smith

Philip Blatcher

John W Mackinnon

William D Ollis

The invention provides compounds of the general formula ##STR1## and physiologically acceptable salts and hydrates thereof, in which one of R.sub.1 and R.sub.2 represents hydrogen, halogen or a C.sub.1-4 alkyl group which may be optionally substituted by hydroxy or C.sub.1-4 alkoxy, and the other represents the group R.sub.4 R.sub.5 NAlk-- in which Alk represents a straight or branched alkylene chain of 1 to 6 carbon atoms;

Heterocyclic derivatives, processes for the use thereof and

The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, and hydrates thereof. The substituents are defined in the specification. The compounds show pharmacological activity as selective histamine H.sub.2 -antagonists.

1,2,4-Triazole-3-amines, their pharmaceutical compositions and method of

The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts or hydrates thereof, in which the substituents are defined later in the specification. The compounds show pharmacological activity as selective histamine H.sub.2 -antagonists.

Tetrazoles, pharmaceutical use and compositions

The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which the substituents are defined later. The compounds show pharmacological activity as selective histamine H.sub.2 -antagonists.

1,2,4-Triazole-3-amine and 1,2,4 triazole-3,5-diamine compounds and

The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which

Heterocyclic derivatives

The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which

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Royston, United Kingdom

Linda Carey