Kosan Biosciences Incorporated

Linda C Dayem

Daniel V Santi

James T Kealey

Larry Peck

Host cells, such as, are provided with an expression system for making starter units required for biosynthesis of polyketides using the ato pathway.

Recombinant host cells expressing atoAD and capable of making a polyketide using a starter unit

Recombinanthost cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase fromoras well asepimerase can produce S-methylmalonyl CoA, a required substrate for the production of polyketides by most modular polyketide synthases not present in wild-typehost cells.

Genetically modified cells and methods for converting (R)-methylmalonyl CoA to (S)-methylmalonyl CoA

Recombinanthost cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase fromoras well asepimerase can produce S-methylmalonyl CoA, a required substrate for the production of polyketides by most modular polyketide synthases and is not present in wild-typehost cells.

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San Anselmo, CA, United States of America

Linda C Dayem