Seattle Genetics, Inc.

Prolx Pharmaceuticals Corporation

Linda Anne Pestano

Alan F Wahl

Nathalie Scholler

Che-Leung Law

Lynn D Kirkpatrick

Cheu-leung Law

Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing a cancer, comprising administering to a subject the disclosed pharmaceutical compositions.

Treatment of renal cell carcinoma with anti-CD70 antibody-drug conjugates

Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of a CD70-expressing cancer, comprising administering to a subject the disclosed pharmaceutical compositions.

Treatment of B-cell cancers with anti-CD70 antibody-drug conjugates

Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.

Anti-CD70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders

Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders

This invention relates to methods of measuring HIF expression and activity, as well as measuring inhibition of HIF following administration of an HIF inhibitor useful in treating HIF related diseases. The present invention further relates to methods of identifying individuals who will respond to HIF inhibitors. The invention also relates to methods of monitoring a patient response to a given dosage of an HIF inhibitor. The invention also includes assays and kits for performing the methods described herein.

Growing community of inventors

Oro Valley, AZ, United States of America

Linda Anne Pestano