Cbio Limited

Invion Limited

Linda Allison Ward

Christopher Bruce Howard

Barbara Jane Johnson

Dean Jason Naylor

Caroline Amanda Dobbin

Daniel Scott Lambert

Kylie Jane Ralston

Inge E A Flesch

Walter Rene Antonius Van Heumen

Christopher John De Bakker

Jeanette Elizabeth Stok

Richard James Brown

Andrew Leigh James

Dean Jason Taylor

The present invention relates to methods for modulating Toll-like receptor signalling in a subject, or in at least one cell, tissue or organ thereof, methods for treating or preventing a disease or condition in a subject, methods for modulating the production and/or secretion of one or more immunomodulators in a subject, or at least one cell, tissue or organ thereof, wherein said methods involve the administration of chaperonin 10, and wherein the chaperonin 10 associates with a Toll-like receptor in an activation cluster. Also contemplated are associated compositions and uses thereof.

Chaperonin 10-induced immunomodulation

The present invention relates to isolated Chaperonin 10 polypeptides possessing immunomodulatory activity, but lacking, or substantially lacking, protein folding activity.

Modified chaperonin 10

The invention relates generally to chaperonin 10 N-terminal variants. More specifically, the invention relates to chaperonin 10 N-terminal variants with enhanced immunomodulatory capacity and/or enhanced binding affinity for pathogen-associated molecular patterns (PAMPs) and/or damage-associated molecular patterns (DAMPs).

Chaperonin 10 variants

A novel granule dispersion composition which comprises water and, dispersed therein, a finely pulverized, sparingly water-soluble substance. The granule dispersion composition is prepared by dispersing in water a granular material which comprises a specific substance sparingly soluble in water, a polymer, and an oil and has an average particle diameter of 1 &#x3bc;m or smaller and in which the ratio of the total weight of the polymer and oil to the weight of the specific substance is 1.5 or higher.

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Carindale, Australia

Linda Allison Ward