Pci Biotech As

The Norwegian Radium Hospital Research Foundation

Lina Prasmickaite

Kristian Berg

Anders Høgset

Anders Hogset

Torunn E Tjelle

Pal Kristian Selbo

Birgit Øvstebø Engesæter

Pål Kristian Selbo

Anders H Øgset

Gunhild Mari Mælandsmo

Birgit Ovstebo Engesaeter

Gunnhild Mari Maelandsmo

Birgit Ovstebø Engesæter

Gunnhild Mari Mælandsmo

Anders Hoegset

The present invention provides a method of stimulating an immune response to an antigenic molecule, by contacting a cell with the antigenic molecule and with a photosensitizing agent, irradiating the cell, and thereby presenting the antigenic molecule, or part thereof, on the surface of said cell and stimulating an immune response.

Method of stimulating an immune response

The present invention provides a method of expressing an antigenic molecule or a part thereof on the surface of an antigen-presenting cell, said method comprising introducing a molecule into the cell cytosol by photochemical internalisation, wherein said molecule, or a part thereof, is subsequently presented on the surface of said cell. Methods of vaccination comprising this method, together with compositions comprising said cells and uses involving said cells expressing antigenic molecules are also provided.

Method of vaccination

The present invention provides a method for introducing a molecule into the cytosol of a cell in which the cell is contacted with a photosensitising agent, the cell is irradiated with light of a wavelength effective to activate the photosensitising agent and, substantially at the same time or after the irradiation, the cell is contacted with the molecule to be introduced, particularly for use in cancer treatment, gene therapy and vaccination.

Photochemical internalization for delivery of molecules into the cytosol

A method for introducing a molecule into the cytosol of a cell in which the cell is contacted with a photosensitizing agent, the cell is irradiated with light of a wavelength effective to activate the photosensitizing agent and, substantially at the same time or after the irradiation, the cell is contacted with the molecule to be introduced, particularly for use in cancer treatment, gene therapy and vaccination.

Photochemical internalization for virus-mediated molecule delivery into the cyosol

The present invention provides a method for introducing a molecule into the cytosol of a cell in which the cell is contacted with a photosentistising agent, the cell is irradiated with light of a wavelength effective to activate the photosentisitising agent and, substantially at the same time or after the irradiation, the cell is contacted with the molecule to be introduced, particularly for use in cancer treatment, gene therapy and vaccination.

Growing community of inventors

Oslo, Norway

Lina Prasmickaite