La Jolla Cancer Research Foundation

Advanced Polymer Systems, Inc.

Advanced Poymer Systems, Inc.

Lin-Shu Liu

Jorge Heller

Michael Froix

Steven Y Ng

Soan Cheng

William S Craig

Daniel G Mullen

James W Polarek

James R Glass

Kenneth T Dickerson

A composition for the sequestration and sustained delivery of an active ingredient in the form of porous particles, the composition comprising the product of the controlled dehydration of particles formed by the reaction of a polymeric anionic material with a polyvalent cation. The composition may be loaded with an active ingredient by soaking the particles in a solution of the active ingredient; and may then be dehydrated. They may then be soaked in a solution of a polymeric cationic material, to form particles providing the controlled release of the active ingredient.

Bioerodible porous compositions

The present invention provides novel conjugates of a synthetic polypeptide containing RGD or (dR)GD and a biodegradable polymer, hyaluronate. The conjugates are prepared by any one of three different methods provided by the present invention: (1) an epoxide method (2) a sodium periodate method, and (3) a tresyl chloride method. The conjugates prepared by these methods are useful to aid in wound healing and tissue regeneration by providing a temporary matrix for tissue repair. The invention also provides novel RGD-peptides.

Immobilization of peptides to hyaluronate

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Mountain View, CA, United States of America

Lin-Shu Liu