Juventas Cell Therapy Ltd.

Lin Shi

Rui Wang

Yun Liu

Lulu Lv

Fei Wang

Jiaxing Yang

Pan Xie

Mengmeng Cao

Wang Yang

Jianxiang Wang

Min Wang

Na An

Provided in the present disclosure is a method for using a four-plasmid system to prepare modified immune effector cells. The method comprises: forming a lentivirus by using four plasmids within 293T cells, extracting and obtaining the lentivirus, then transfecting immune effector cells by using the lentivirus, and expressing a chimeric antigen receptor. Also provided in the present disclosure is a use of the immune effector cell obtained by using the described method and of a composition containing the immune effector cell.

Plasmid combination and application thereof in preparing modified immune cells

A chimeric antigen receptor, comprising an amino acid sequence shown in SEQ ID NO. 1. A nucleic acid encoding the chimeric antigen receptor, a vector comprising the nucleic acid, an immune effector cell comprising the chimeric antigen receptor, the nucleic acid molecule and/or the vector, a method for preparing the immune effector cell, a composition comprising the immune effector cell, and use of the chimeric antigen receptor.

CD19-targeted chimeric antigen receptor and use thereof

Growing community of inventors

Tianjin, China

Lin Shi