Los Angeles Biomedical Research Institute at Harbor-ucla Medical Center

Lin Lin

Brad J Spellberg

Ashraf S Ibrahim

Guanpingsheng Luo

The present invention provides vaccine and pharmaceutical compositions for treating or preventing bacterial inventions. The vaccine compositions of the invention include a carbapenemase such as a serine carbapenemase, a metallo-&#x3b2;-lactamase or an immunogenic fragment thereof. The pharmaceutical compositions include an anti-carbapenemase antibody or fragment thereof. Also provided are methods for treating and preventing a bacterial infection using the vaccine and pharmaceutical compositions of the invention. The invention further provides antibody conjugates that include an antibody or fragment thereof conjugated to a siderophore or an analog thereof.

Compositions and methods for immunization against bacteria expressing a carbapenemase

The present invention provides vaccine compositions comprising OmpA, or antigenic fragments thereof, and related methods of active immunization againstinfection. The invention also provides antibodies and antigen-binding parts thereof that specifically bind to OmpA, and related methods of passive immunization againstinfection. The compositions and methods of the invention are useful for preventing or treatinginfections, including those caused by strains resistant to carbapenems and all other antibiotics except colistin or tigecycline, also referred to as extreme drug resistant (XDR)infections, and those resistant to every FDA approved antibiotic, also referred to as pan-drug resistant (PDR)infections.

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Rancho Palos Verdes, CA, United States of America

Lin Lin